Sugi Predict

Sugi Predict / Compounds / SCHEMBL827045

SCHEMBL827045

SCHEMBL827045

O=C(Cl)Cc1cccc(C(F)(F)F)c1

nearest known ligand 0.59

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
▸ MEN1 O00255 3/20 0.59
▸ KMT2A Q03164 3/20 0.59
▸ MAPT P10636 1/20 0.59
▸ ACP3 P15309 1/20 0.56
▸ LMNA P02545 1/20 0.52
▸ TAAR1 Q96RJ0 1/20 0.51
▸ HDAC1 Q13547 2/20 0.51
▸ HDAC8 Q9BY41 2/20 0.51
▸ EPHX1 P07099 1/20 0.51
▸ PLA2G1B P04054 1/20 0.51
▸ CYP1A2 P05177 1/20 0.51
▸ CYP3A4 P08684 1/20 0.51
▸ GAA P10253 1/20 0.51
▸ CYP2D6 P10635 1/20 0.51
▸ CYP2C19 P33261 1/20 0.51
▸ TDP1 Q9NUW8 1/20 0.51
▸ ATG4B Q9Y4P1 1/20 0.51
▸ SMYD3 Q9H7B4 1/20 0.51
▸ HTT P42858 2/20 0.50
▸ HDAC3 O15379 1/20 0.50

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL6865758 0.85 MEN1 (0.62) MEN1KMT2AMAPTACP3TAAR1
SCHEMBL11808569 0.84 MEN1 (0.60) MEN1KMT2AMAPTACP3LMNA
SCHEMBL378581 0.84 MEN1 (0.65) MEN1KMT2AMAPTACP3TAAR1
SCHEMBL29935522 0.84 MEN1 (0.65) MEN1KMT2AMAPTACP3TAAR1
SCHEMBL16575624 0.83 TAAR1 (0.57) MEN1KMT2AMAPTACP3TAAR1
SCHEMBL30089386 0.83 TAAR1 (0.57) MEN1KMT2AMAPTACP3TAAR1
SCHEMBL2407518 0.83 MEN1 (0.56) MEN1KMT2AMAPTACP3LMNA
Hydrochloric Acid SCHEMBL2525493 0.82 MEN1 (0.63) MEN1KMT2AMAPTACP3TAAR1
SCHEMBL6710664 0.82 MEN1 (0.59) MEN1KMT2AMAPTACP3LMNA
SCHEMBL265041 0.82 MEN1 (0.59) MEN1KMT2AMAPTACP3TAAR1

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 158 patents — showing the first 20. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
US-20200165238-A1 Heterocyclic Inhibitors of Glutaminase CALITHERA BIOSCIENCES INC. 2020-05-28 — — US claimed
EP-3620162-A1 HETEROCYCLIC INHIBITORS OF GLUTAMINASE Calithera Biosciences Inc. (US) 2020-03-11 — — EP claimed
US-20260070903-A1 NOVEL PYRIDO[3,4-D]PYRIMIDIN-8-ONE DERIVATIVE HAVING PROTEIN KINASE INHIBITORY ACTIVITY, AND PHARMACEUTICAL COMPOSITION FOR PREVENTING, ALLEVIATING, OR TREATING CANCER, COMPRISING SAME KOREA INSTITUTE OF SCIENCE AND TECHNOLOGY (KR) 2026-03-12 — — US disclosed
CN-118619909-A Epigenetic medicine for lncRNA-PSF interaction, composition and application thereof 山东铂源药业股份有限公司 2024-09-10 — — CN disclosed
CN-113646307-B Pyrido [3,4-d ] pyrimidin-8-one derivatives having protein kinase inhibitory activity and pharmaceutical compositions thereof 韩国科学技术研究院 2024-07-30 — — CN disclosed
CN-117551057-A Benzo ring derivative and preparation method and application thereof 浙江海正药业股份有限公司 2024-02-13 — — CN disclosed
US-20240000075-A1 FUNGICIDAL ARYL AMIDINES CORTEVA AGRISCIENCE LLC (US) 2024-01-04 — — US disclosed
EP-4247788-A1 FUNGICIDAL ARYL AMIDINES Corteva Agriscience LLC (US) 2023-09-27 — — EP disclosed
CN-116715634-A Compound, pharmaceutical composition and application thereof in preparation of vasodilation drugs 山东第一医科大学(山东省医学科学院) 2023-09-08 — — CN disclosed
CN-116457340-A Fungicidal aryl amidines 科迪华农业科技有限责任公司 2023-07-18 — — CN disclosed
WO-2022109361-A1 FUNGICIDAL ARYL AMIDINES CORTEVA AGRISCIENCE LLC (US) 2022-05-27 — — WO disclosed
US-4212888-A Anilide derivatives as antidepressants THE UPJOHN COMPANY (US) 1980-07-15 — — US disclosed
US-4200572-A Substituted azetidinones SMITHKLINE CORPORATION (US) 1980-04-29 — — US disclosed
US-4128663-A Anilide derivatives as antidepressants THE UPJOHN COMPANY (US) 1978-12-05 — — US disclosed
US-4102669-A IN COTTON CULTURE ELI LILLY AND COMPANY (US) 1978-07-25 — — US disclosed
US-4065290-A Herbicidal β-phenyl-4-piperidinones ELI LILLY AND COMPANY (US) 1977-12-27 — — US disclosed
US-4065473-A Intermediates in the preparation of 2,3,4,5-tetrahydro-1H-3-benzazepines HOFFMANN-LA ROCHE INC. (US) 1977-12-27 — — US disclosed
US-4054665-A 2-Amino-5-(trifluoromethylphenylalkyl)-1,3,4 thiadiazoles used in the treatment of insomnia and anxiety SANDOZ, INC. (US) 1977-10-18 — — US disclosed
US-4000154-A 3-Substituted-6β-(amino- and acylamino)-7-oxo-1,3-diazabicyclo[3.2.0]-h SMITHKLINE CORPORATION (US) 1976-12-28 — — US disclosed
US-3965110-A 2-Amino-5-(trifluoromethyl phenylalkyl)-1,3,4-thiadiazoles SANDOZ, INC. (US) 1976-06-22 — — US disclosed

Patent text — is the patent's own abstract consistent with the prediction?

For each of this compound's patents that has machine-readable text (3 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.

PatentTitleText reads most aboutPredicted target · text-rank
US-20200165238-A1 Heterocyclic Inhibitors of Glutaminase GLS, GLS2, GLUL MEN1 1027/4885KMT2A 850/4885MAPT 3123/4885
US-20240000075-A1 FUNGICIDAL ARYL AMIDINES CYP1A1, CYP1A2, CYP1B1 MEN1 1445/4885KMT2A 1220/4885MAPT 4011/4885
US-20260070903-A1 NOVEL PYRIDO[3,4-D]PYRIMIDIN-8-ONE DERIVATIVE HAVING PROTEIN KINASE INHIBITORY ACTIVITY, AND PHARMACEUTICAL COMPOSITION FOR PREVENTING, ALLEVIATING, OR TREATING CANCER, COMPRISING SAME CCNC, CKS1B, CKS2 MEN1 2374/4885KMT2A 3441/4885MAPT 4069/4885

“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.