Predicted protein targets (top 11)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | LMNA | P02545 | 1/20 | 0.46 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.46 |
| ▸ | RAB9A | P51151 | 4/20 | 0.44 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.44 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.43 |
| ▸ | NPC1 | O15118 | 1/20 | 0.43 |
| ▸ | POLB | P06746 | 1/20 | 0.42 |
| ▸ | HSD11B1 | P28845 | 5/20 | 0.41 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.40 |
| ▸ | KCNH2 | Q12809 | 1/20 | 0.40 |
| ▸ | FAAH | O00519 | 1/20 | 0.40 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL4227209 | 0.80 | NOTUM (0.44) | LMNAMAPK1RAB9ANPC1HSD11B1 | |
| SCHEMBL12506166 | 0.77 | GPR119 (0.51) | LMNARAB9AALDH1A1NPC1POLB | |
| SCHEMBL12490134 | 0.75 | FAAH (0.47) | LMNARAB9ANPC1POLBFAAH | |
| SCHEMBL4234552 | 0.74 | SMN1; SMN2 (0.48) | LMNARAB9AALDH1A1POLBHSD11B1 | |
| SCHEMBL29040325 | 0.74 | FAAH (0.47) | LMNAALDH1A1POLBHSD11B1FAAH | |
| SCHEMBL14349266 | 0.72 | ACACB (0.43) | LMNARAB9ANPC1POLBHSD11B1 | |
| SCHEMBL27814281 | 0.72 | HTT (0.58) | LMNAMAPK1FAAH | |
| SCHEMBL8272507 | 0.72 | MEN1 (0.43) | LMNARAB9AALDH1A1POLB | |
| SCHEMBL17115053 | 0.71 | FAAH (0.48) | ALDH1A1POLBCYP2D6KCNH2FAAH | |
| SCHEMBL12490987 | 0.70 | FAAH (0.50) | LMNARAB9ANPC1HSD11B1CYP2D6 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2006017409-A2 | 1,3-DISUBSTITUTED HETEROARYL NMDA/NR2B ANTAGONISTS | MERCK & CO., INC. (US) | 2006-02-16 | — | — | WO | disclosed |