Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HPGDS | O60760 | 1/20 | 0.38 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.37 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.37 |
| ▸ | ADAM17 | P78536 | 1/20 | 0.35 |
| ▸ | HDAC3 | O15379 | 1/20 | 0.34 |
| ▸ | HDAC1 | Q13547 | 1/20 | 0.34 |
| ▸ | HDAC2 | Q92769 | 1/20 | 0.34 |
| ▸ | RPS6KB1 | P23443 | 2/20 | 0.33 |
| ▸ | PDE6D | O43924 | 1/20 | 0.33 |
| ▸ | HRAS | P01112 | 1/20 | 0.33 |
| ▸ | KRAS | P01116 | 1/20 | 0.33 |
| ▸ | DGAT2 | Q96PD7 | 1/20 | 0.33 |
| ▸ | DPP8 | Q6V1X1 | 3/20 | 0.33 |
| ▸ | DPP9 | Q86TI2 | 3/20 | 0.33 |
| ▸ | DPP7 | Q9UHL4 | 3/20 | 0.33 |
| ▸ | DPP4 | P27487 | 2/20 | 0.33 |
| ▸ | PIM1 | P11309 | 1/20 | 0.32 |
| ▸ | HTT | P42858 | 2/20 | 0.32 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.32 |
| ▸ | GAA | P10253 | 1/20 | 0.32 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL8275469 | 0.91 | ADAM17 (0.36) | HPGDSALDH1A1ADAM17HDAC1HDAC2 | |
| SCHEMBL8217550 | 0.89 | ADAM17 (0.44) | HPGDSADAM17RPS6KB1NAMPT | |
| SCHEMBL8274740 | 0.87 | HPGDS (0.36) | HPGDSALDH1A1L3MBTL1HDAC3HDAC1 | |
| SCHEMBL8274407 | 0.86 | ADAM17 (0.43) | ALDH1A1L3MBTL1ADAM17DPP8DPP9 | |
| SCHEMBL8276118 | 0.86 | ADAM17 (0.43) | ALDH1A1L3MBTL1ADAM17DPP8DPP9 | |
| SCHEMBL8275285 | 0.85 | NAMPT (0.42) | HDAC1HDAC2NAMPT | |
| SCHEMBL8275981 | 0.83 | NAMPT (0.42) | ALDH1A1L3MBTL1ADAM17RPS6KB1DPP8 | |
| SCHEMBL8273591 | 0.82 | ADAM17 (0.43) | ALDH1A1L3MBTL1ADAM17HDAC3HDAC1 | |
| SCHEMBL8273310 | 0.82 | GAA (0.44) | ALDH1A1L3MBTL1ADAM17RPS6KB1PDE6D | |
| SCHEMBL8273592 | 0.81 | HTT (0.46) | ALDH1A1L3MBTL1ADAM17DPP7DPP4 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2005121130-A2 | CHEMICAL COMPOUNDS AND PHARMACEUTICAL COMPOSITIONS CONTAINING THEM FOR THE TREATMENT OF INFLAMMATORY DISORDERS | SCHERING CORPORATION (US) | 2005-12-22 | — | — | WO | disclosed |