Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ADAM17 | P78536 | 13/20 | 0.47 |
| ▸ | KDM4E | B2RXH2 | 3/20 | 0.42 |
| ▸ | HTT | P42858 | 2/20 | 0.42 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.38 |
| ▸ | GAA | P10253 | 2/20 | 0.38 |
| ▸ | ADAM10 | O14672 | 1/20 | 0.38 |
| ▸ | MMP1 | P03956 | 1/20 | 0.38 |
| ▸ | MMP2 | P08253 | 1/20 | 0.38 |
| ▸ | MMP3 | P08254 | 1/20 | 0.38 |
| ▸ | MMP13 | P45452 | 1/20 | 0.38 |
| ▸ | MMP14 | P50281 | 1/20 | 0.38 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.38 |
| ▸ | NPC1 | O15118 | 1/20 | 0.37 |
| ▸ | MAPT | P10636 | 1/20 | 0.37 |
| ▸ | HPGD | P15428 | 1/20 | 0.37 |
| ▸ | RAB9A | P51151 | 1/20 | 0.37 |
| ▸ | POLB | P06746 | 1/20 | 0.36 |
| ▸ | NR4A1 | P22736 | 1/20 | 0.36 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.36 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.36 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL8273310 | 0.86 | GAA (0.44) | ADAM17KDM4EHTTALDH1A1GAA | |
| SCHEMBL8273591 | 0.86 | ADAM17 (0.43) | ADAM17KDM4EHTTALDH1A1GAA | |
| SCHEMBL8273592 | 0.85 | HTT (0.46) | ADAM17KDM4EHTTALDH1A1GAA | |
| SCHEMBL8275186 | 0.83 | ADAM17 (0.70) | ADAM17ADAM10MMP2MMP3MMP13 | |
| SCHEMBL8273579 | 0.82 | CTSS (0.41) | ADAM17KDM4EHTTALDH1A1GAA | |
| SCHEMBL8273588 | 0.82 | ADAM17 (0.40) | ADAM17KDM4EHTTALDH1A1GAA | |
| SCHEMBL8273578 | 0.81 | ADAM17 (0.39) | ADAM17KDM4EHTTALDH1A1GAA | |
| SCHEMBL8274407 | 0.81 | ADAM17 (0.43) | ADAM17HTTALDH1A1GAAL3MBTL1 | |
| SCHEMBL8276118 | 0.81 | ADAM17 (0.43) | ADAM17HTTALDH1A1GAAL3MBTL1 | |
| SCHEMBL8273311 | 0.81 | ADAM17 (0.41) | ADAM17KDM4EHTTALDH1A1GAA |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2005121130-A2 | CHEMICAL COMPOUNDS AND PHARMACEUTICAL COMPOSITIONS CONTAINING THEM FOR THE TREATMENT OF INFLAMMATORY DISORDERS | SCHERING CORPORATION (US) | 2005-12-22 | — | — | WO | disclosed |