Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | P2RX7 | Q99572 | 1/20 | 0.43 |
| ▸ | EPHX1 | P07099 | 1/20 | 0.37 |
| ▸ | GAA | P10253 | 2/20 | 0.35 |
| ▸ | MEN1 | O00255 | 2/20 | 0.35 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.35 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.35 |
| ▸ | CTSL | P07711 | 1/20 | 0.35 |
| ▸ | CA2 | P00918 | 2/20 | 0.34 |
| ▸ | CA12 | O43570 | 1/20 | 0.34 |
| ▸ | CA14 | Q9ULX7 | 1/20 | 0.34 |
| ▸ | APLNR | P35414 | 1/20 | 0.34 |
| ▸ | PPIA | P62937 | 1/20 | 0.34 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.33 |
| ▸ | USP2 | O75604 | 1/20 | 0.33 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.33 |
| ▸ | LMNA | P02545 | 1/20 | 0.33 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.33 |
| ▸ | TSHR | P16473 | 1/20 | 0.33 |
| ▸ | BLM | P54132 | 1/20 | 0.33 |
| ▸ | CACNA2D1 | P54289 | 1/20 | 0.33 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL1134597 | 0.98 | P2RX7 (0.41) | P2RX7EPHX1GAAMEN1KMT2A | |
| SCHEMBL16081548 | 0.95 | P2RX7 (0.39) | P2RX7EPHX1GAAMEN1KMT2A | |
| SCHEMBL1752478 | 0.91 | MEN1 (0.37) | P2RX7EPHX1GAAMEN1KMT2A | |
| Hydrochloric Acid SCHEMBL28213668 | 0.90 | MEN1 (0.36) | P2RX7EPHX1GAAMEN1KMT2A | |
| SCHEMBL14851186 | 0.86 | P2RX7 (0.34) | P2RX7MEN1KMT2AMAPK1CTSL | |
| SCHEMBL3365305 | 0.85 | P2RX7 (0.40) | P2RX7EPHX1GAAMEN1KMT2A | |
| SCHEMBL14334492 | 0.85 | P2RX7 (0.44) | P2RX7EPHX1GAAMEN1KMT2A | |
| SCHEMBL12975362 | 0.85 | P2RX7 (0.44) | P2RX7EPHX1GAAMEN1KMT2A | |
| SCHEMBL941564 | 0.85 | P2RX7 (0.44) | P2RX7EPHX1GAAMEN1KMT2A | |
| SCHEMBL22765980 | 0.84 | P2RX7 (0.42) | P2RX7EPHX1GAAMEN1KMT2A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 20 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-12264135-B2 | Synthesis of 1,4-diazaspiro[5.5]undecan-3-one | PHARMACOSMOS HOLDING A/S (DK) | 2025-04-01 | — | — | US | disclosed |
| US-20240199556-A1 | Synthesis of 1,4-Diazaspiro[5.5]Undecan-3-One | G1 THERAPEUTICS, INC. (US) | 2024-06-20 | — | — | US | disclosed |
| US-11708337-B2 | Synthesis of 1,4-diazaspiro[5.5]undecan-3-one | G1 THERAPEUTICS, INC. (US) | 2023-07-25 | — | — | US | disclosed |
| CN-109641864-B | Anti-infective agents | 邓迪大学 | 2023-04-04 | — | — | CN | disclosed |
| US-11485720-B2 | Anti-infective agents | UNIVERSITY OF DUNDEE (GB) | 2022-11-01 | — | — | US | disclosed |
| EP-3472141-B1 | ANTI-INFECTIVE AGENTS | UNIV DUNDEE (GB) | 2022-10-05 | — | — | EP | disclosed |
| US-20210179567-A1 | SYNTHESIS OF 1,4-DIAZASPIRO[5.5]UNDECAN-3-ONE | G1 THERAPEUTICS, INC. (US) | 2021-06-17 | — | — | US | disclosed |
| US-20210101877-A1 | ANTI-INFECTIVE AGENTS | UNIVERSITY OF DUNDEE (GB) | 2021-04-08 | — | — | US | disclosed |
| US-20190225592-A1 | ANTI-INFECTIVE AGENTS | UNIVERSITY OF DUNDEE (GB) | 2019-07-25 | — | — | US | disclosed |
| EP-3472141-A1 | ANTI-INFECTIVE AGENTS | University Of Dundee (GB) | 2019-04-24 | — | — | EP | disclosed |
| CN-109641864-A | ANTI-INFECTIVE AGENTS | 邓迪大学 | 2019-04-16 | — | — | CN | disclosed |
| WO-2017221002-A1 | ANTI-INFECTIVE AGENTS | UNIVERSITY OF DUNDEE (GB) | 2017-12-28 | — | — | WO | disclosed |
| CN-104981470-B | Amino-substituted imidazo[1,2-a]pyridinecarboxamides and their use | 拜耳制药股份公司 | 2017-04-19 | — | — | CN | disclosed |
| CN-104981470-A | Amino-substituted imidazo[1,2-a]pyridinecarboxamides and their use | Bayer Pharma AG | 2015-10-14 | — | — | CN | disclosed |
| CN-102015705-B | Fused heterocyclic derivative and use thereof | TAKEDA PHARMACEUTICAL | 2013-11-13 | — | — | CN | disclosed |
| EP-1730142-B1 | NOVEL KETOAMIDES WITH CYCLIC P4'S AS INHIBITORS OF NS3 SERINE PROTEASE OF HEPATITIS C VIRUS | SCHERING CORP (US) | 2011-06-29 | — | — | EP | disclosed |
| US-7619094-B2 | Ketoamides with cyclic P4's as inhibitors of NS3 serine protease of hepatitis C virus | SCHERING CORPORATION (US) | 2009-11-17 | — | — | US | disclosed |
| US-20070093430-A1 | Novel ketoamides with cyclic P4's as inhibitors of NS3 serine protease of hepatitis C virus | MERCK SHARP & DOHME CORP. | 2007-04-26 | — | — | US | disclosed |
| US-7173057-B2 | Ketoamides with cyclic P4'S as inhibitors of NS3 protease of hepatitis C virus | SCHERING CORPORATION (US) | 2007-02-06 | — | — | US | disclosed |
| WO-2005085242-A1 | NOVEL KETOAMIDES WITH CYCLIC P4'S AS INHIBITORS OF NS3 SERINE PROTEASE OF HEPATITIS C VIRUS | SCHERING CORPORATION (US) | 2005-09-15 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (8 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-11485720-B2 | Anti-infective agents | C1R, RRS1, ARG1 | P2RX7 206/4885EPHX1 1977/4885GAA 1799/4885 |
| US-12264135-B2 | Synthesis of 1,4-diazaspiro[5.5]undecan-3-one | NDC1, SDC1, SDC2 | P2RX7 2807/4885EPHX1 3393/4885GAA 1852/4885 |
| US-11708337-B2 | Synthesis of 1,4-diazaspiro[5.5]undecan-3-one | NDC1, SDC1, SDC2 | P2RX7 2807/4885EPHX1 3393/4885GAA 1852/4885 |
| US-20070093430-A1 | Novel ketoamides with cyclic P4's as inhibitors of NS3 serine protease of hepatitis C virus | PREP, PRSS1, P4HB | P2RX7 1824/4885EPHX1 751/4885GAA 1711/4885 |
| US-20210101877-A1 | ANTI-INFECTIVE AGENTS | C1R, RRS1, ARG1 | P2RX7 206/4885EPHX1 1977/4885GAA 1799/4885 |
| US-20210179567-A1 | SYNTHESIS OF 1,4-DIAZASPIRO[5.5]UNDECAN-3-ONE | NDC1, SDC1, SDC2 | P2RX7 2807/4885EPHX1 3393/4885GAA 1852/4885 |
| US-20190225592-A1 | ANTI-INFECTIVE AGENTS | C1R, ARG1, MSR1 | P2RX7 191/4885EPHX1 1954/4885GAA 1593/4885 |
| US-20240199556-A1 | Synthesis of 1,4-Diazaspiro[5.5]Undecan-3-One | NDC1, SDC1, SDC2 | P2RX7 2807/4885EPHX1 3393/4885GAA 1852/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.