Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KCNH3 | Q9ULD8 | 3/20 | 0.44 |
| ▸ | ALDH1A1 | P00352 | 6/20 | 0.37 |
| ▸ | KDM4E | B2RXH2 | 4/20 | 0.37 |
| ▸ | MAPT | P10636 | 2/20 | 0.37 |
| ▸ | GAA | P10253 | 3/20 | 0.35 |
| ▸ | HPGD | P15428 | 3/20 | 0.35 |
| ▸ | GLA | P06280 | 1/20 | 0.35 |
| ▸ | CASP1 | P29466 | 1/20 | 0.35 |
| ▸ | CASP7 | P55210 | 1/20 | 0.35 |
| ▸ | ATM | Q13315 | 1/20 | 0.35 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.35 |
| ▸ | LMNA | P02545 | 3/20 | 0.35 |
| ▸ | L3MBTL1 | Q9Y468 | 2/20 | 0.35 |
| ▸ | MEN1 | O00255 | 1/20 | 0.35 |
| ▸ | HTT | P42858 | 1/20 | 0.35 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.35 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.35 |
| ▸ | PDE11A | Q9HCR9 | 1/20 | 0.35 |
| ▸ | FYN | P06241 | 1/20 | 0.34 |
| ▸ | MKNK1 | Q9BUB5 | 1/20 | 0.34 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL8286094 | 0.89 | PDE11A (0.45) | KCNH3ALDH1A1KDM4EMAPTGAA | |
| SCHEMBL8287107 | 0.80 | PDE11A (0.48) | KCNH3ALDH1A1KDM4EMAPTGAA | |
| SCHEMBL8287864 | 0.79 | PDE11A (0.44) | KCNH3ALDH1A1KDM4EMAPTGAA | |
| SCHEMBL8287857 | 0.79 | PDE11A (0.56) | KCNH3ALDH1A1KDM4EMAPTGAA | |
| SCHEMBL8285185 | 0.77 | CSNK2A2 (0.39) | ALDH1A1PDE11ACFTRSMN1; SMN2POLB | |
| SCHEMBL8285186 | 0.76 | ADORA3 (0.37) | ALDH1A1KDM4EMAPTGAAHPGD | |
| SCHEMBL8287115 | 0.76 | PDE11A (0.44) | KCNH3ALDH1A1KDM4EMAPTGAA | |
| SCHEMBL8286089 | 0.75 | PDE11A (0.45) | KCNH3ALDH1A1KDM4EMAPTHPGD | |
| SCHEMBL8287365 | 0.75 | GRM5 (0.38) | ALDH1A1KDM4EMAPTGAAMEN1 | |
| SCHEMBL8286091 | 0.75 | PDE11A (0.46) | KCNH3ALDH1A1CASP1CASP7HSD17B10 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2005091857-A2 | 1,6-NAPHTHYRIDINE AND 1,8-NAPHTHYRIDINE DERIVATIVES AND THEIR USE TO TREAT DIABETES AND RELATED DISORDERS | BAYER PHARMACEUTICALS CORPORATION (US) | 2005-10-06 | — | — | WO | disclosed |
| WO-2003027112-A1 | 1, 8-NAPHTHYRIDINE DERIVATIVES AS ANTIDIABETICS | BAYER PHARMACEUTICALS CORPORATION (US) | 2003-04-03 | — | — | WO | disclosed |