Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PDE11A | Q9HCR9 | 1/20 | 0.53 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.41 |
| ▸ | MEN1 | O00255 | 3/20 | 0.41 |
| ▸ | KMT2A | Q03164 | 3/20 | 0.41 |
| ▸ | USP2 | O75604 | 2/20 | 0.41 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.41 |
| ▸ | HTT | P42858 | 1/20 | 0.41 |
| ▸ | HPGD | P15428 | 3/20 | 0.38 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.38 |
| ▸ | EPHX2 | P34913 | 1/20 | 0.37 |
| ▸ | EPHX1 | P07099 | 1/20 | 0.37 |
| ▸ | IGSF11 | Q5DX21 | 1/20 | 0.37 |
| ▸ | RAB9A | P51151 | 1/20 | 0.36 |
| ▸ | LMNA | P02545 | 2/20 | 0.36 |
| ▸ | TSHR | P16473 | 2/20 | 0.36 |
| ▸ | TP53 | P04637 | 1/20 | 0.36 |
| ▸ | MAPT | P10636 | 2/20 | 0.35 |
| ▸ | POLB | P06746 | 1/20 | 0.35 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.35 |
| ▸ | RXFP1 | Q9HBX9 | 2/20 | 0.35 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL8285263 | 0.87 | PDE11A (0.56) | PDE11AMEN1KMT2AHTTTP53 | |
| SCHEMBL8362903 | 0.86 | PDE11A (0.56) | PDE11AALDH1A1MEN1KMT2AHTT | |
| SCHEMBL8285254 | 0.86 | PDE11A (0.59) | PDE11AALDH1A1MEN1KMT2AKDM4E | |
| SCHEMBL8287479 | 0.85 | PDE11A (0.57) | PDE11AALDH1A1MEN1KMT2AUSP2 | |
| SCHEMBL8285266 | 0.85 | PDE11A (0.57) | PDE11AALDH1A1MEN1KMT2AKDM4E | |
| SCHEMBL8285257 | 0.84 | PDE11A (0.57) | PDE11AALDH1A1MEN1KMT2AHTT | |
| SCHEMBL8285280 | 0.82 | PDE11A (0.56) | PDE11AALDH1A1MEN1KMT2AKDM4E | |
| SCHEMBL8285258 | 0.82 | PDE11A (0.55) | PDE11AALDH1A1MEN1KMT2AHTT | |
| SCHEMBL8287887 | 0.80 | PDE11A (0.57) | PDE11AALDH1A1MEN1KMT2AUSP2 | |
| SCHEMBL8285287 | 0.78 | PDE11A (0.63) | PDE11AALDH1A1MEN1KMT2AUSP2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2005091857-A2 | 1,6-NAPHTHYRIDINE AND 1,8-NAPHTHYRIDINE DERIVATIVES AND THEIR USE TO TREAT DIABETES AND RELATED DISORDERS | BAYER PHARMACEUTICALS CORPORATION (US) | 2005-10-06 | — | — | WO | disclosed |
| WO-2003027112-A1 | 1, 8-NAPHTHYRIDINE DERIVATIVES AS ANTIDIABETICS | BAYER PHARMACEUTICALS CORPORATION (US) | 2003-04-03 | — | — | WO | disclosed |