Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | GABRA1 | P14867 | 2/20 | 0.40 |
| ▸ | GABRG2 | P18507 | 2/20 | 0.40 |
| ▸ | GABRB3 | P28472 | 2/20 | 0.40 |
| ▸ | GABRA5 | P31644 | 2/20 | 0.40 |
| ▸ | GABRA3 | P34903 | 2/20 | 0.40 |
| ▸ | GABRA2 | P47869 | 2/20 | 0.40 |
| ▸ | GABRP | O00591 | 1/20 | 0.40 |
| ▸ | GABRD | O14764 | 1/20 | 0.40 |
| ▸ | GABRB1 | P18505 | 1/20 | 0.40 |
| ▸ | GABRB2 | P47870 | 1/20 | 0.40 |
| ▸ | GABRA4 | P48169 | 1/20 | 0.40 |
| ▸ | GABRE | P78334 | 1/20 | 0.40 |
| ▸ | GABRA6 | Q16445 | 1/20 | 0.40 |
| ▸ | GABRG1 | Q8N1C3 | 1/20 | 0.40 |
| ▸ | GABRG3 | Q99928 | 1/20 | 0.40 |
| ▸ | GABRQ | Q9UN88 | 1/20 | 0.40 |
| ▸ | CSF1R | P07333 | 1/20 | 0.36 |
| ▸ | GSK3B | P49841 | 4/20 | 0.36 |
| ▸ | HPGD | P15428 | 3/20 | 0.36 |
| ▸ | MAPT | P10636 | 3/20 | 0.36 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL8287920 | 0.93 | CSF1R (0.37) | CSF1RGSK3BHPGDMAPTKDM4E | |
| SCHEMBL8287523 | 0.88 | GSK3B (0.37) | CSF1RGSK3BHPGDMAPTALDH1A1 | |
| SCHEMBL8286468 | 0.87 | GSK3B (0.38) | CSF1RGSK3BHPGDMAPTALDH1A1 | |
| SCHEMBL8287593 | 0.87 | GSK3B (0.37) | GABRA1GABRG2GABRB3GABRA5GABRA3 | |
| SCHEMBL8287205 | 0.86 | GSK3B (0.37) | CSF1RGSK3BEGFRBTKCDK4 | |
| SCHEMBL8287486 | 0.86 | LMNA (0.37) | CSF1RGSK3BHPGDMAPTALDH1A1 | |
| SCHEMBL8287930 | 0.86 | CSF1R (0.47) | GABRA1GABRG2GABRB3GABRA5GABRA3 | |
| SCHEMBL8362924 | 0.84 | GSK3B (0.39) | CSF1RGSK3BHPGDMAPTALDH1A1 | |
| SCHEMBL8286472 | 0.84 | EGFR (0.46) | MAPTALDH1A1KDM4ENPC1RAB9A | |
| SCHEMBL8287526 | 0.84 | MAPK13 (0.38) | GSK3BMAPTKDM4ENPC1RAB9A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2005091857-A2 | 1,6-NAPHTHYRIDINE AND 1,8-NAPHTHYRIDINE DERIVATIVES AND THEIR USE TO TREAT DIABETES AND RELATED DISORDERS | BAYER PHARMACEUTICALS CORPORATION (US) | 2005-10-06 | — | — | WO | disclosed |
| WO-2003027112-A1 | 1, 8-NAPHTHYRIDINE DERIVATIVES AS ANTIDIABETICS | BAYER PHARMACEUTICALS CORPORATION (US) | 2003-04-03 | — | — | WO | disclosed |