Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | EGFR | P00533 | 2/20 | 0.46 |
| ▸ | LCK | P06239 | 1/20 | 0.46 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.43 |
| ▸ | NPC1 | O15118 | 1/20 | 0.43 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.43 |
| ▸ | RAB9A | P51151 | 1/20 | 0.43 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.39 |
| ▸ | P4HTM | Q9NXG6 | 1/20 | 0.39 |
| ▸ | POLB | P06746 | 1/20 | 0.38 |
| ▸ | KDR | P35968 | 4/20 | 0.38 |
| ▸ | HMOX1 | P09601 | 1/20 | 0.38 |
| ▸ | HMOX2 | P30519 | 1/20 | 0.38 |
| ▸ | CNR1 | P21554 | 1/20 | 0.38 |
| ▸ | TOP2A | P11388 | 1/20 | 0.37 |
| ▸ | NR3C1 | P04150 | 1/20 | 0.37 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.36 |
| ▸ | MAPT | P10636 | 1/20 | 0.36 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.36 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.36 |
| ▸ | KMO | O15229 | 1/20 | 0.36 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL8287593 | 0.90 | GSK3B (0.37) | EGFRLCKNPC1ALDH1A1RAB9A | |
| SCHEMBL8287205 | 0.89 | GSK3B (0.37) | EGFRLCK | |
| SCHEMBL8286468 | 0.88 | GSK3B (0.38) | EGFRKDM4ENPC1ALDH1A1RAB9A | |
| SCHEMBL8287936 | 0.87 | RIPK1 (0.40) | EGFRLCKPOLBNPSR1 | |
| SCHEMBL8287526 | 0.87 | MAPK13 (0.38) | EGFRKDM4ENPC1RAB9ASMN1; SMN2 | |
| SCHEMBL8287968 | 0.86 | RIPK1 (0.41) | EGFRNPC1RAB9AMAPT | |
| SCHEMBL8362924 | 0.85 | GSK3B (0.39) | EGFRALDH1A1RAB9AKMT2AMAPT | |
| SCHEMBL8287920 | 0.85 | CSF1R (0.37) | EGFRKDM4ENPC1RAB9ASMN1; SMN2 | |
| SCHEMBL8285291 | 0.84 | GABRA1 (0.40) | EGFRKDM4ENPC1ALDH1A1RAB9A | |
| SCHEMBL5871843 | 0.82 | MAT2A (0.40) | KDM4EALDH1A1SMN1; SMN2KMT2AMAPT |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2005091857-A2 | 1,6-NAPHTHYRIDINE AND 1,8-NAPHTHYRIDINE DERIVATIVES AND THEIR USE TO TREAT DIABETES AND RELATED DISORDERS | BAYER PHARMACEUTICALS CORPORATION (US) | 2005-10-06 | — | — | WO | disclosed |
| WO-2003027112-A1 | 1, 8-NAPHTHYRIDINE DERIVATIVES AS ANTIDIABETICS | BAYER PHARMACEUTICALS CORPORATION (US) | 2003-04-03 | — | — | WO | disclosed |