Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MAPK13 | O15264 | 3/20 | 0.38 |
| ▸ | MAPK12 | P53778 | 3/20 | 0.38 |
| ▸ | MAPK11 | Q15759 | 3/20 | 0.38 |
| ▸ | MAPK14 | Q16539 | 3/20 | 0.38 |
| ▸ | MAPT | P10636 | 2/20 | 0.36 |
| ▸ | NPC1 | O15118 | 1/20 | 0.36 |
| ▸ | RAB9A | P51151 | 1/20 | 0.36 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.36 |
| ▸ | GSK3B | P49841 | 5/20 | 0.35 |
| ▸ | CDK4 | P11802 | 1/20 | 0.35 |
| ▸ | CCND1 | P24385 | 1/20 | 0.35 |
| ▸ | CCND2 | P30279 | 1/20 | 0.35 |
| ▸ | CCND3 | P30281 | 1/20 | 0.35 |
| ▸ | ABL1 | P00519 | 1/20 | 0.35 |
| ▸ | SRC | P12931 | 1/20 | 0.35 |
| ▸ | ADORA3 | P0DMS8 | 1/20 | 0.35 |
| ▸ | ADORA1 | P30542 | 1/20 | 0.35 |
| ▸ | GAA | P10253 | 1/20 | 0.34 |
| ▸ | GFER | P55789 | 1/20 | 0.34 |
| ▸ | PDE11A | Q9HCR9 | 1/20 | 0.34 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL8287593 | 0.90 | GSK3B (0.37) | MAPTNPC1RAB9ASMN1; SMN2GSK3B | |
| SCHEMBL8287205 | 0.89 | GSK3B (0.37) | GSK3BCDK4CCND1CCND2CCND3 | |
| SCHEMBL8286468 | 0.88 | GSK3B (0.38) | MAPTNPC1RAB9ASMN1; SMN2GSK3B | |
| SCHEMBL8286472 | 0.87 | EGFR (0.46) | MAPTNPC1RAB9ASMN1; SMN2KMT2A | |
| SCHEMBL8286489 | 0.86 | ALDH1A1 (0.36) | MAPTNPC1RAB9ASMN1; SMN2GAA | |
| SCHEMBL8287920 | 0.85 | CSF1R (0.37) | MAPK13MAPK12MAPK11MAPK14MAPT | |
| SCHEMBL8362924 | 0.85 | GSK3B (0.39) | MAPK13MAPK12MAPK11MAPK14MAPT | |
| SCHEMBL8287968 | 0.84 | RIPK1 (0.41) | MAPK14MAPTNPC1RAB9AHTT | |
| SCHEMBL8285291 | 0.84 | GABRA1 (0.40) | MAPTNPC1RAB9ASMN1; SMN2GSK3B | |
| SCHEMBL8287936 | 0.83 | RIPK1 (0.40) | GSK3BPDE11AEGFR |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2005091857-A2 | 1,6-NAPHTHYRIDINE AND 1,8-NAPHTHYRIDINE DERIVATIVES AND THEIR USE TO TREAT DIABETES AND RELATED DISORDERS | BAYER PHARMACEUTICALS CORPORATION (US) | 2005-10-06 | — | — | WO | disclosed |
| WO-2003027112-A1 | 1, 8-NAPHTHYRIDINE DERIVATIVES AS ANTIDIABETICS | BAYER PHARMACEUTICALS CORPORATION (US) | 2003-04-03 | — | — | WO | disclosed |