Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | LMNA | P02545 | 2/20 | 0.37 |
| ▸ | TSHR | P16473 | 2/20 | 0.37 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.36 |
| ▸ | MAPT | P10636 | 2/20 | 0.36 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.36 |
| ▸ | CSF1R | P07333 | 1/20 | 0.35 |
| ▸ | GSK3B | P49841 | 3/20 | 0.35 |
| ▸ | CDK4 | P11802 | 1/20 | 0.34 |
| ▸ | CCND1 | P24385 | 1/20 | 0.34 |
| ▸ | CCND2 | P30279 | 1/20 | 0.34 |
| ▸ | CCND3 | P30281 | 1/20 | 0.34 |
| ▸ | POLB | P06746 | 1/20 | 0.34 |
| ▸ | RAB9A | P51151 | 1/20 | 0.34 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.34 |
| ▸ | MEN1 | O00255 | 1/20 | 0.34 |
| ▸ | PKM | P14618 | 1/20 | 0.34 |
| ▸ | HPGD | P15428 | 1/20 | 0.34 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.34 |
| ▸ | MAT2A | P31153 | 2/20 | 0.34 |
| ▸ | PDE11A | Q9HCR9 | 1/20 | 0.34 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL8287920 | 0.87 | CSF1R (0.37) | LMNAMAPTCSF1RGSK3BCDK4 | |
| SCHEMBL8285291 | 0.86 | GABRA1 (0.40) | LMNAALDH1A1MAPTCSF1RGSK3B | |
| SCHEMBL8286468 | 0.85 | GSK3B (0.38) | LMNAALDH1A1MAPTCSF1RGSK3B | |
| SCHEMBL8287201 | 0.85 | GSK3B (0.34) | TSHRALDH1A1MAPTCSF1RGSK3B | |
| SCHEMBL8287593 | 0.85 | GSK3B (0.37) | TSHRALDH1A1MAPTGSK3BCDK4 | |
| SCHEMBL8287205 | 0.84 | GSK3B (0.37) | CSF1RGSK3BCDK4CCND1CCND2 | |
| SCHEMBL8287930 | 0.84 | CSF1R (0.47) | LMNAALDH1A1MAPTCSF1RMEN1 | |
| SCHEMBL8362924 | 0.82 | GSK3B (0.39) | ALDH1A1MAPTCSF1RGSK3BCDK4 | |
| SCHEMBL8286472 | 0.82 | EGFR (0.46) | ALDH1A1MAPTPOLBRAB9AKMT2A | |
| SCHEMBL8287526 | 0.82 | MAPK13 (0.38) | MAPTGSK3BCDK4CCND1CCND2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2005091857-A2 | 1,6-NAPHTHYRIDINE AND 1,8-NAPHTHYRIDINE DERIVATIVES AND THEIR USE TO TREAT DIABETES AND RELATED DISORDERS | BAYER PHARMACEUTICALS CORPORATION (US) | 2005-10-06 | — | — | WO | disclosed |
| WO-2003027112-A1 | 1, 8-NAPHTHYRIDINE DERIVATIVES AS ANTIDIABETICS | BAYER PHARMACEUTICALS CORPORATION (US) | 2003-04-03 | — | — | WO | disclosed |