Predicted protein targets (top 3)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | OPRM1 | P35372 | 9/20 | 0.64 |
| ▸ | OPRD1 | P41143 | 8/20 | 0.64 |
| ▸ | OPRK1 | P41145 | 8/20 | 0.64 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL3114799 | 1.00 | OPRM1 (0.64) | OPRM1OPRD1OPRK1 | |
| SCHEMBL17168337 | 1.00 | OPRM1 (0.64) | OPRM1OPRD1OPRK1 | |
| SCHEMBL16437865 | 1.00 | OPRM1 (0.64) | OPRM1OPRD1OPRK1 | |
| SCHEMBL10050599 | 1.00 | OPRM1 (0.64) | OPRM1OPRD1OPRK1 | |
| SCHEMBL138329 | 1.00 | OPRM1 (0.64) | OPRM1OPRD1OPRK1 | |
| SCHEMBL10301493 | 1.00 | OPRM1 (0.64) | OPRM1OPRD1OPRK1 | |
| SCHEMBL14883433 | 1.00 | OPRM1 (0.64) | OPRM1OPRD1OPRK1 | |
| SCHEMBL16926031 | 1.00 | OPRM1 (0.64) | OPRM1OPRD1OPRK1 | |
| SCHEMBL20683157 | 1.00 | OPRM1 (0.64) | OPRM1OPRD1OPRK1 | |
| SCHEMBL102247 | 1.00 | OPRM1 (0.64) | OPRM1OPRD1OPRK1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 7 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-8063060-B2 | R(−)-11-hydroxyaporphine derivatives and uses thereof | THE MCLEAN HOSPITAL CORPORATION (US) | 2011-11-22 | — | — | US | disclosed |
| US-8063060-B2 | R(−)-11-hydroxyaporphine derivatives and uses thereof | THE MCLEAN HOSPITAL CORPORATION (US) | 2011-11-22 | — | — | US | disclosed |
| US-20100081651-A1 | R(-)-11-HYDROXYAPORPHINE DERIVATIVES AND USES THEREOF | THE MCLEAN HOSPITAL CORPORATION (US) | 2010-04-01 | — | — | US | disclosed |
| US-20100081651-A1 | R(-)-11-HYDROXYAPORPHINE DERIVATIVES AND USES THEREOF | THE MCLEAN HOSPITAL CORPORATION (US) | 2010-04-01 | — | — | US | disclosed |
| US-7648995-B2 | R(—)-11-hydroxyaporphine derivatives and uses thereof | THE MCLEAN HOSPITAL CORPORATION (US) | 2010-01-19 | — | — | US | disclosed |
| US-7648995-B2 | R(—)-11-hydroxyaporphine derivatives and uses thereof | THE MCLEAN HOSPITAL CORPORATION (US) | 2010-01-19 | — | — | US | disclosed |
| WO-2005099702-A2 | R(-)-11-HYDROXYAPORPHINE DERIVATIVES AND USES THEREOF | THE MCLEAN HOSPITAL CORPORATION (US) | 2005-10-27 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20100081651-A1 | R(-)-11-HYDROXYAPORPHINE DERIVATIVES AND USES THEREOF | SNCA, HTR5A, HTR3A | OPRM1 88/4885OPRD1 44/4885OPRK1 59/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.