Predicted protein targets (top 9)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HRH3 | Q9Y5N1 | 13/20 | 0.50 |
| ▸ | KCNH2 | Q12809 | 4/20 | 0.50 |
| ▸ | CYP2C9 | P11712 | 6/20 | 0.43 |
| ▸ | CYP3A4 | P08684 | 4/20 | 0.43 |
| ▸ | HPGD | P15428 | 1/20 | 0.43 |
| ▸ | SLC18A3 | Q16572 | 1/20 | 0.40 |
| ▸ | SIGMAR1 | Q99720 | 1/20 | 0.40 |
| ▸ | NAAA | Q02083 | 1/20 | 0.39 |
| ▸ | HTR2C | P28335 | 1/20 | 0.39 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL8490308 | 0.86 | HRH3 (0.50) | HRH3KCNH2CYP2C9CYP3A4SLC18A3 | |
| SCHEMBL8490059 | 0.81 | KDM4E (0.60) | HRH3KCNH2CYP2C9HPGD | |
| SCHEMBL8492021 | 0.81 | SLC18A3 (0.59) | HRH3KCNH2SLC18A3SIGMAR1HTR2C | |
| SCHEMBL8484170 | 0.80 | HTR1A (0.54) | HRH3KCNH2SLC18A3SIGMAR1HTR2C | |
| SCHEMBL8234772 | 0.80 | HTR2C (0.45) | HRH3KCNH2CYP2C9CYP3A4SLC18A3 | |
| SCHEMBL11832143 | 0.79 | MAOA (0.55) | HRH3KCNH2CYP2C9SLC18A3SIGMAR1 | |
| SCHEMBL6132905 | 0.78 | HRH3 (0.48) | HRH3KCNH2HPGDSIGMAR1 | |
| SCHEMBL8285809 | 0.78 | ESRRB (0.46) | HRH3KCNH2CYP2C9CYP3A4SLC18A3 | |
| SCHEMBL22117595 | 0.77 | SLC18A3 (0.48) | HRH3KCNH2CYP2C9CYP3A4SLC18A3 | |
| SCHEMBL18553710 | 0.77 | HRH1 (0.53) | HRH3HPGDSLC18A3SIGMAR1HTR2C |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1707202-A1 | Organic compounds | Speedel Experimenta AG (CH) | 2006-10-04 | — | — | EP | disclosed |
| WO-2005061457-A1 | ORGANIC COMPOUNDS | SPEEDEL EXPERIMENTA AG (CH) | 2005-07-07 | — | — | WO | disclosed |