Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | GSK3B | P49841 | 3/20 | 0.36 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.34 |
| ▸ | FPR1 | P21462 | 1/20 | 0.34 |
| ▸ | CSF1R | P07333 | 1/20 | 0.34 |
| ▸ | MAT2A | P31153 | 4/20 | 0.34 |
| ▸ | CDK4 | P11802 | 2/20 | 0.33 |
| ▸ | CCND1 | P24385 | 2/20 | 0.33 |
| ▸ | CCND2 | P30279 | 2/20 | 0.33 |
| ▸ | CCND3 | P30281 | 2/20 | 0.33 |
| ▸ | PDE11A | Q9HCR9 | 1/20 | 0.33 |
| ▸ | GAA | P10253 | 3/20 | 0.33 |
| ▸ | HPGD | P15428 | 2/20 | 0.33 |
| ▸ | MAPK1 | P28482 | 2/20 | 0.33 |
| ▸ | EGFR | P00533 | 1/20 | 0.32 |
| ▸ | BTK | Q06187 | 1/20 | 0.32 |
| ▸ | CYP11B1 | P15538 | 1/20 | 0.32 |
| ▸ | CYP11B2 | P19099 | 1/20 | 0.32 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.31 |
| ▸ | MAPT | P10636 | 1/20 | 0.31 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.31 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL8286154 | 0.86 | GSK3B (0.42) | GSK3BCYP2C9MAT2ACDK4CCND1 | |
| SCHEMBL8287920 | 0.82 | CSF1R (0.37) | GSK3BCYP2C9FPR1CSF1RMAT2A | |
| SCHEMBL8286150 | 0.81 | GSK3B (0.39) | GSK3BCSF1RMAT2ACDK4CCND1 | |
| SCHEMBL8286502 | 0.80 | MAPT (0.33) | GSK3BCYP2C9CDK4CCND1CCND2 | |
| SCHEMBL5872050 | 0.80 | GAA (0.44) | GSK3BCYP2C9MAT2ACDK4CCND1 | |
| SCHEMBL8285261 | 0.80 | GSK3B (0.38) | GSK3BCSF1RMAT2ACDK4CCND1 | |
| SCHEMBL8287486 | 0.80 | LMNA (0.37) | GSK3BCSF1RMAT2ACDK4CCND1 | |
| SCHEMBL8286516 | 0.79 | LMNA (0.39) | MAT2AGAAHPGDKDM4EMAPT | |
| SCHEMBL8287617 | 0.79 | GSK3B (0.37) | GSK3BCSF1RMAT2ACDK4CCND1 | |
| SCHEMBL8286162 | 0.79 | GSK3B (0.37) | GSK3BCSF1RMAT2ACDK4CCND1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2005091857-A2 | 1,6-NAPHTHYRIDINE AND 1,8-NAPHTHYRIDINE DERIVATIVES AND THEIR USE TO TREAT DIABETES AND RELATED DISORDERS | BAYER PHARMACEUTICALS CORPORATION (US) | 2005-10-06 | — | — | WO | disclosed |
| WO-2003027112-A1 | 1, 8-NAPHTHYRIDINE DERIVATIVES AS ANTIDIABETICS | BAYER PHARMACEUTICALS CORPORATION (US) | 2003-04-03 | — | — | WO | disclosed |