Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MAPT | P10636 | 3/20 | 0.33 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.33 |
| ▸ | USP2 | O75604 | 3/20 | 0.33 |
| ▸ | CYP1A2 | P05177 | 3/20 | 0.33 |
| ▸ | CASP1 | P29466 | 3/20 | 0.33 |
| ▸ | MEN1 | O00255 | 2/20 | 0.33 |
| ▸ | CASP7 | P55210 | 2/20 | 0.33 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.33 |
| ▸ | CYP3A4 | P08684 | 2/20 | 0.33 |
| ▸ | CLK4 | Q9HAZ1 | 2/20 | 0.33 |
| ▸ | LMNA | P02545 | 2/20 | 0.33 |
| ▸ | HBB | P68871 | 1/20 | 0.33 |
| ▸ | BRCA1 | P38398 | 1/20 | 0.33 |
| ▸ | GSK3B | P49841 | 3/20 | 0.32 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.32 |
| ▸ | CDK4 | P11802 | 1/20 | 0.31 |
| ▸ | CCND1 | P24385 | 1/20 | 0.31 |
| ▸ | CCND2 | P30279 | 1/20 | 0.31 |
| ▸ | CCND3 | P30281 | 1/20 | 0.31 |
| ▸ | PDE11A | Q9HCR9 | 1/20 | 0.31 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL8286154 | 0.80 | GSK3B (0.42) | USP2CYP1A2CASP1MEN1CASP7 | |
| SCHEMBL8286151 | 0.80 | GSK3B (0.36) | MAPTHSD17B10LMNAGSK3BALDH1A1 | |
| SCHEMBL8286516 | 0.80 | LMNA (0.39) | MAPTHSD17B10CYP1A2MEN1KMT2A | |
| SCHEMBL8286508 | 0.79 | LOXL3 (0.42) | HSD17B10USP2CYP1A2CASP1MEN1 | |
| SCHEMBL8286489 | 0.78 | ALDH1A1 (0.36) | MAPTHSD17B10USP2MEN1KMT2A | |
| SCHEMBL8287593 | 0.77 | GSK3B (0.37) | MAPTMEN1KMT2AGSK3BALDH1A1 | |
| SCHEMBL8362929 | 0.76 | PIK3CA (0.44) | MAPTMEN1KMT2ALMNAGSK3B | |
| SCHEMBL8285183 | 0.76 | PDE11A (0.41) | MAPTHSD17B10USP2CYP1A2CASP1 | |
| SCHEMBL5872050 | 0.74 | GAA (0.44) | MAPTUSP2CYP1A2CASP1MEN1 | |
| SCHEMBL8287197 | 0.74 | EGFR (0.43) | MAPTMEN1KMT2ALMNAGSK3B |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2005091857-A2 | 1,6-NAPHTHYRIDINE AND 1,8-NAPHTHYRIDINE DERIVATIVES AND THEIR USE TO TREAT DIABETES AND RELATED DISORDERS | BAYER PHARMACEUTICALS CORPORATION (US) | 2005-10-06 | — | — | WO | disclosed |
| WO-2003027112-A1 | 1, 8-NAPHTHYRIDINE DERIVATIVES AS ANTIDIABETICS | BAYER PHARMACEUTICALS CORPORATION (US) | 2003-04-03 | — | — | WO | disclosed |