Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | DRD2 | P14416 | 2/20 | 0.39 |
| ▸ | DRD3 | P35462 | 2/20 | 0.39 |
| ▸ | PDE11A | Q9HCR9 | 1/20 | 0.39 |
| ▸ | GAA | P10253 | 1/20 | 0.37 |
| ▸ | KIT | P10721 | 2/20 | 0.37 |
| ▸ | MAPT | P10636 | 2/20 | 0.36 |
| ▸ | MAPK1 | P28482 | 2/20 | 0.36 |
| ▸ | MEN1 | O00255 | 1/20 | 0.36 |
| ▸ | HCRTR1 | O43613 | 1/20 | 0.36 |
| ▸ | USP2 | O75604 | 1/20 | 0.36 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.36 |
| ▸ | POLB | P06746 | 1/20 | 0.36 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.36 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.36 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.36 |
| ▸ | HTT | P42858 | 1/20 | 0.36 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.36 |
| ▸ | MTNR1B | P49286 | 1/20 | 0.36 |
| ▸ | P2RY12 | Q9H244 | 4/20 | 0.36 |
| ▸ | CNR1 | P21554 | 1/20 | 0.36 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL8287910 | 0.89 | MAPT (0.43) | PDE11AMAPTMAPK1MEN1USP2 | |
| SCHEMBL8287935 | 0.88 | NCF1 (0.43) | PDE11AGAAMAPTMAPK1MEN1 | |
| SCHEMBL8286461 | 0.86 | PDE11A (0.47) | DRD2DRD3PDE11AGAAMAPT | |
| SCHEMBL8287531 | 0.84 | PDE11A (0.44) | DRD2DRD3PDE11AGAAMAPT | |
| SCHEMBL8287461 | 0.84 | MAT2A (0.44) | PDE11AGAAMAPTMAPK1CYP1A2 | |
| SCHEMBL8287408 | 0.83 | PDE11A (0.44) | PDE11AGAAMAPTMAPK1MEN1 | |
| SCHEMBL8287925 | 0.82 | PDE11A (0.42) | PDE11AGAAMAPTMAPK1MEN1 | |
| SCHEMBL8287403 | 0.82 | PDE11A (0.56) | PDE11AMAPTMAPK1CYP1A2CYP3A4 | |
| SCHEMBL8287402 | 0.80 | PDE11A (0.39) | DRD2DRD3PDE11APOLBP2RY12 | |
| SCHEMBL8287468 | 0.78 | P2RY12 (0.41) | PDE11AKITMAPTMAPK1MEN1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2005091857-A2 | 1,6-NAPHTHYRIDINE AND 1,8-NAPHTHYRIDINE DERIVATIVES AND THEIR USE TO TREAT DIABETES AND RELATED DISORDERS | BAYER PHARMACEUTICALS CORPORATION (US) | 2005-10-06 | — | — | WO | disclosed |
| WO-2003027112-A1 | 1, 8-NAPHTHYRIDINE DERIVATIVES AS ANTIDIABETICS | BAYER PHARMACEUTICALS CORPORATION (US) | 2003-04-03 | — | — | WO | disclosed |