Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MAT2A | P31153 | 1/20 | 0.44 |
| ▸ | PDE11A | Q9HCR9 | 1/20 | 0.44 |
| ▸ | ADRA2A | P08913 | 2/20 | 0.43 |
| ▸ | ADRA2B | P18089 | 2/20 | 0.43 |
| ▸ | ADRA2C | P18825 | 2/20 | 0.43 |
| ▸ | ADORA3 | P0DMS8 | 1/20 | 0.41 |
| ▸ | ADORA2A | P29274 | 1/20 | 0.41 |
| ▸ | CDK4 | P11802 | 1/20 | 0.41 |
| ▸ | CCND1 | P24385 | 1/20 | 0.41 |
| ▸ | CCND2 | P30279 | 1/20 | 0.41 |
| ▸ | CCND3 | P30281 | 1/20 | 0.41 |
| ▸ | KDM1A | O60341 | 5/20 | 0.39 |
| ▸ | MAPT | P10636 | 1/20 | 0.39 |
| ▸ | GPR55 | Q9Y2T6 | 1/20 | 0.39 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.38 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.37 |
| ▸ | CYP1A2 | P05177 | 2/20 | 0.37 |
| ▸ | CASP1 | P29466 | 2/20 | 0.37 |
| ▸ | HSD17B10 | Q99714 | 2/20 | 0.37 |
| ▸ | GLA | P06280 | 1/20 | 0.37 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL8286461 | 0.94 | PDE11A (0.47) | MAT2APDE11AADRA2AADRA2BADRA2C | |
| SCHEMBL8287408 | 0.91 | PDE11A (0.44) | MAT2APDE11AADORA3ADORA2AMAPT | |
| SCHEMBL8287925 | 0.89 | PDE11A (0.42) | PDE11AMAPTALDH1A1HSD17B10GAA | |
| SCHEMBL8287403 | 0.89 | PDE11A (0.56) | MAT2APDE11AADORA3ADORA2AMAPT | |
| SCHEMBL8287935 | 0.88 | NCF1 (0.43) | PDE11ACDK4CCND1CCND2CCND3 | |
| SCHEMBL8287402 | 0.87 | PDE11A (0.39) | MAT2APDE11A | |
| SCHEMBL8287910 | 0.85 | MAPT (0.43) | PDE11AMAPTL3MBTL1ALDH1A1MAPK1 | |
| SCHEMBL8286167 | 0.84 | DRD2 (0.39) | PDE11AMAPTGPR55ALDH1A1CYP1A2 | |
| SCHEMBL8286539 | 0.83 | PDE11A (0.42) | PDE11AADORA2AMAPTL3MBTL1ALDH1A1 | |
| SCHEMBL8286110 | 0.82 | PDE11A (0.50) | MAT2APDE11AADRA2AADRA2BADRA2C |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2005091857-A2 | 1,6-NAPHTHYRIDINE AND 1,8-NAPHTHYRIDINE DERIVATIVES AND THEIR USE TO TREAT DIABETES AND RELATED DISORDERS | BAYER PHARMACEUTICALS CORPORATION (US) | 2005-10-06 | — | — | WO | disclosed |
| WO-2003027112-A1 | 1, 8-NAPHTHYRIDINE DERIVATIVES AS ANTIDIABETICS | BAYER PHARMACEUTICALS CORPORATION (US) | 2003-04-03 | — | — | WO | disclosed |