Predicted protein targets (top 16)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ALDH1A1 | P00352 | 4/20 | 0.39 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.39 |
| ▸ | CHRM2 | P08172 | 1/20 | 0.38 |
| ▸ | CHRM4 | P08173 | 1/20 | 0.38 |
| ▸ | CHRM1 | P11229 | 1/20 | 0.38 |
| ▸ | CHRM3 | P20309 | 1/20 | 0.38 |
| ▸ | GRM5 | P41594 | 1/20 | 0.38 |
| ▸ | PTGS2 | P35354 | 1/20 | 0.37 |
| ▸ | MALT1 | Q9UDY8 | 1/20 | 0.36 |
| ▸ | MAPT | P10636 | 2/20 | 0.36 |
| ▸ | GAA | P10253 | 1/20 | 0.36 |
| ▸ | RAB9A | P51151 | 1/20 | 0.35 |
| ▸ | PRMT3 | O60678 | 3/20 | 0.35 |
| ▸ | ACHE | P22303 | 1/20 | 0.35 |
| ▸ | TP53 | P04637 | 2/20 | 0.34 |
| ▸ | POLB | P06746 | 2/20 | 0.34 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL8286178 | 0.86 | GAA (0.36) | ALDH1A1MAPTGAARAB9A | |
| SCHEMBL8286211 | 0.84 | MAP3K8 (0.34) | MAPTGAA | |
| SCHEMBL8286557 | 0.83 | NPC1 (0.40) | ALDH1A1KMT2AGRM5MAPTGAA | |
| SCHEMBL8286173 | 0.83 | GAA (0.36) | ALDH1A1KMT2AMAPTGAARAB9A | |
| SCHEMBL8287258 | 0.83 | GRM5 (0.45) | ALDH1A1KMT2ACHRM2CHRM4CHRM1 | |
| SCHEMBL8286182 | 0.82 | MAT2A (0.46) | ALDH1A1GAA | |
| SCHEMBL8286432 | 0.81 | KMT2A (0.39) | ALDH1A1KMT2ACHRM2CHRM4CHRM1 | |
| SCHEMBL8287246 | 0.81 | GAA (0.39) | ALDH1A1KMT2APTGS2MAPTGAA | |
| SCHEMBL8287276 | 0.80 | MAT2A (0.40) | MAPTGAARAB9A | |
| SCHEMBL8286174 | 0.79 | BRAF (0.39) | ALDH1A1KMT2AMAPTGAARAB9A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2005091857-A2 | 1,6-NAPHTHYRIDINE AND 1,8-NAPHTHYRIDINE DERIVATIVES AND THEIR USE TO TREAT DIABETES AND RELATED DISORDERS | BAYER PHARMACEUTICALS CORPORATION (US) | 2005-10-06 | — | — | WO | disclosed |
| WO-2003027112-A1 | 1, 8-NAPHTHYRIDINE DERIVATIVES AS ANTIDIABETICS | BAYER PHARMACEUTICALS CORPORATION (US) | 2003-04-03 | — | — | WO | disclosed |