Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | GRM5 | P41594 | 1/20 | 0.45 |
| ▸ | HPGD | P15428 | 4/20 | 0.42 |
| ▸ | SMN1; SMN2 | Q16637 | 3/20 | 0.41 |
| ▸ | CSF1R | P07333 | 1/20 | 0.39 |
| ▸ | ALDH1A1 | P00352 | 6/20 | 0.39 |
| ▸ | HSD17B10 | Q99714 | 3/20 | 0.39 |
| ▸ | CYP2C9 | P11712 | 2/20 | 0.39 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.39 |
| ▸ | LMNA | P02545 | 2/20 | 0.39 |
| ▸ | MEN1 | O00255 | 1/20 | 0.39 |
| ▸ | GLA | P06280 | 1/20 | 0.39 |
| ▸ | GAA | P10253 | 1/20 | 0.39 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.38 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.38 |
| ▸ | HTT | P42858 | 2/20 | 0.38 |
| ▸ | MAPT | P10636 | 1/20 | 0.38 |
| ▸ | ALOX15 | P16050 | 1/20 | 0.38 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.38 |
| ▸ | CHRM2 | P08172 | 1/20 | 0.37 |
| ▸ | CHRM4 | P08173 | 1/20 | 0.37 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL8287991 | 0.85 | GAA (0.39) | HPGDSMN1; SMN2CSF1RALDH1A1GAA | |
| SCHEMBL8360822 | 0.83 | CSF1R (0.37) | GRM5HPGDSMN1; SMN2CSF1RALDH1A1 | |
| SCHEMBL8286184 | 0.83 | ALDH1A1 (0.39) | GRM5ALDH1A1KMT2AGAAMAPT | |
| SCHEMBL8360854 | 0.82 | MAPK14 (0.38) | HPGDSMN1; SMN2ALDH1A1CYP2C9KMT2A | |
| SCHEMBL8287257 | 0.82 | RAB9A (0.40) | HPGDSMN1; SMN2ALDH1A1CYP2C9KMT2A | |
| SCHEMBL8286557 | 0.81 | NPC1 (0.40) | GRM5ALDH1A1KMT2AMEN1GAA | |
| SCHEMBL8287252 | 0.81 | CXCR2 (0.37) | HPGDCSF1RALDH1A1HSD17B10CYP2C9 | |
| SCHEMBL8362709 | 0.81 | PDE11A (0.39) | HPGDSMN1; SMN2CSF1RALDH1A1CYP2C9 | |
| SCHEMBL8287253 | 0.80 | RIPK1 (0.43) | HTTMAPTPOLB | |
| SCHEMBL8361774 | 0.80 | RIPK1 (0.42) | ALDH1A1KDM4E |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2005091857-A2 | 1,6-NAPHTHYRIDINE AND 1,8-NAPHTHYRIDINE DERIVATIVES AND THEIR USE TO TREAT DIABETES AND RELATED DISORDERS | BAYER PHARMACEUTICALS CORPORATION (US) | 2005-10-06 | — | — | WO | disclosed |
| WO-2003027112-A1 | 1, 8-NAPHTHYRIDINE DERIVATIVES AS ANTIDIABETICS | BAYER PHARMACEUTICALS CORPORATION (US) | 2003-04-03 | — | — | WO | disclosed |