Predicted protein targets (top 14)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ALDH1A1 | P00352 | 10/20 | 0.43 |
| ▸ | TSHR | P16473 | 2/20 | 0.43 |
| ▸ | HPGD | P15428 | 5/20 | 0.43 |
| ▸ | HSD17B10 | Q99714 | 3/20 | 0.42 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.42 |
| ▸ | MAPT | P10636 | 1/20 | 0.42 |
| ▸ | MEN1 | O00255 | 2/20 | 0.41 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.41 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.41 |
| ▸ | USP2 | O75604 | 2/20 | 0.40 |
| ▸ | PKM | P14618 | 1/20 | 0.40 |
| ▸ | PDE11A | Q9HCR9 | 1/20 | 0.40 |
| ▸ | CSF1R | P07333 | 1/20 | 0.40 |
| ▸ | HTT | P42858 | 1/20 | 0.39 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL8361765 | 0.90 | GAA (0.45) | ALDH1A1HPGDHSD17B10KDM4ESMN1; SMN2 | |
| SCHEMBL8286356 | 0.87 | CYP3A4 (0.41) | ALDH1A1TSHRKDM4EMAPTSMN1; SMN2 | |
| SCHEMBL8287463 | 0.87 | SMN1; SMN2 (0.48) | ALDH1A1TSHRKDM4EMAPTKMT2A | |
| SCHEMBL8286368 | 0.85 | PDE11A (0.44) | ALDH1A1TSHRHPGDKDM4EMAPT | |
| SCHEMBL8286039 | 0.84 | ALDH1A1 (0.43) | ALDH1A1TSHRHPGDHSD17B10MAPT | |
| SCHEMBL8286358 | 0.83 | USP2 (0.46) | ALDH1A1KDM4EMEN1KMT2ASMN1; SMN2 | |
| SCHEMBL8361761 | 0.83 | ALDH1A1 (0.42) | ALDH1A1TSHRHPGDHSD17B10KDM4E | |
| SCHEMBL8286402 | 0.83 | ALDH1A1 (0.43) | ALDH1A1HPGDHSD17B10KDM4EMAPT | |
| SCHEMBL8286414 | 0.82 | CSF1R (0.47) | ALDH1A1HPGDHSD17B10KDM4EMAPT | |
| SCHEMBL8287819 | 0.82 | PDE11A (0.53) | ALDH1A1TSHRHPGDHSD17B10MAPT |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2005091857-A2 | 1,6-NAPHTHYRIDINE AND 1,8-NAPHTHYRIDINE DERIVATIVES AND THEIR USE TO TREAT DIABETES AND RELATED DISORDERS | BAYER PHARMACEUTICALS CORPORATION (US) | 2005-10-06 | — | — | WO | disclosed |
| WO-2003027112-A1 | 1, 8-NAPHTHYRIDINE DERIVATIVES AS ANTIDIABETICS | BAYER PHARMACEUTICALS CORPORATION (US) | 2003-04-03 | — | — | WO | disclosed |