Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ALDH1A1 | P00352 | 6/20 | 0.43 |
| ▸ | KDM4E | B2RXH2 | 5/20 | 0.43 |
| ▸ | MEN1 | O00255 | 3/20 | 0.43 |
| ▸ | KMT2A | Q03164 | 3/20 | 0.43 |
| ▸ | HPGD | P15428 | 2/20 | 0.43 |
| ▸ | GAA | P10253 | 2/20 | 0.43 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.43 |
| ▸ | POLB | P06746 | 1/20 | 0.43 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.43 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.43 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.43 |
| ▸ | CSF1R | P07333 | 1/20 | 0.42 |
| ▸ | MAPT | P10636 | 4/20 | 0.42 |
| ▸ | HSD17B10 | Q99714 | 2/20 | 0.42 |
| ▸ | PDE11A | Q9HCR9 | 1/20 | 0.41 |
| ▸ | KLK7 | P49862 | 1/20 | 0.39 |
| ▸ | HTT | P42858 | 1/20 | 0.39 |
| ▸ | NPC1 | O15118 | 1/20 | 0.39 |
| ▸ | RAB9A | P51151 | 1/20 | 0.39 |
| ▸ | PTGDR2 | Q9Y5Y4 | 1/20 | 0.38 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL8286366 | 0.91 | PDE11A (0.43) | ALDH1A1KDM4EMEN1KMT2AHPGD | |
| SCHEMBL8286408 | 0.88 | RAB9A (0.41) | ALDH1A1KDM4ECYP1A2POLBCYP2C9 | |
| SCHEMBL8287417 | 0.88 | HTT (0.47) | ALDH1A1KDM4EHPGDCYP1A2CYP2C9 | |
| SCHEMBL8286418 | 0.84 | LDHA (0.45) | ALDH1A1KDM4EMEN1KMT2AHPGD | |
| SCHEMBL8361761 | 0.83 | ALDH1A1 (0.42) | ALDH1A1KDM4EMEN1KMT2AHPGD | |
| SCHEMBL8286414 | 0.83 | CSF1R (0.47) | ALDH1A1KDM4EMEN1KMT2AHPGD | |
| SCHEMBL8286379 | 0.83 | PDE11A (0.43) | ALDH1A1KDM4EMEN1KMT2AHPGD | |
| SCHEMBL8286357 | 0.83 | ALDH1A1 (0.43) | ALDH1A1KDM4EMEN1KMT2AHPGD | |
| SCHEMBL8287532 | 0.83 | PDE11A (0.51) | ALDH1A1KDM4EKMT2AHPGDGAA | |
| SCHEMBL8287832 | 0.82 | PDE11A (0.47) | ALDH1A1KDM4EMEN1KMT2AHPGD |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2005091857-A2 | 1,6-NAPHTHYRIDINE AND 1,8-NAPHTHYRIDINE DERIVATIVES AND THEIR USE TO TREAT DIABETES AND RELATED DISORDERS | BAYER PHARMACEUTICALS CORPORATION (US) | 2005-10-06 | — | — | WO | disclosed |
| WO-2003027112-A1 | 1, 8-NAPHTHYRIDINE DERIVATIVES AS ANTIDIABETICS | BAYER PHARMACEUTICALS CORPORATION (US) | 2003-04-03 | — | — | WO | disclosed |