Predicted protein targets (top 16)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CYP3A4 | P08684 | 1/20 | 0.41 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.41 |
| ▸ | HTT | P42858 | 1/20 | 0.41 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.41 |
| ▸ | RAB9A | P51151 | 1/20 | 0.41 |
| ▸ | PDE11A | Q9HCR9 | 1/20 | 0.40 |
| ▸ | PNP | P00491 | 1/20 | 0.39 |
| ▸ | GAA | P10253 | 2/20 | 0.38 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.38 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.38 |
| ▸ | TSHR | P16473 | 1/20 | 0.38 |
| ▸ | MAPT | P10636 | 1/20 | 0.37 |
| ▸ | TAS2R14 | Q9NYV8 | 1/20 | 0.37 |
| ▸ | USP2 | O75604 | 1/20 | 0.37 |
| ▸ | LMNA | P02545 | 1/20 | 0.37 |
| ▸ | POLB | P06746 | 1/20 | 0.37 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL8287463 | 0.91 | SMN1; SMN2 (0.48) | HTTSMN1; SMN2GAAALDH1A1KDM4E | |
| SCHEMBL8361765 | 0.90 | GAA (0.45) | SMN1; SMN2PDE11AGAAALDH1A1KDM4E | |
| SCHEMBL8286357 | 0.87 | ALDH1A1 (0.43) | HTTSMN1; SMN2PDE11AALDH1A1KDM4E | |
| SCHEMBL8286358 | 0.87 | USP2 (0.46) | HTTSMN1; SMN2PDE11APNPALDH1A1 | |
| SCHEMBL8286368 | 0.85 | PDE11A (0.44) | HTTSMN1; SMN2PDE11AGAAALDH1A1 | |
| SCHEMBL8361762 | 0.83 | OPRK1 (0.41) | HTTSMN1; SMN2RAB9APDE11AGAA | |
| SCHEMBL8286408 | 0.82 | RAB9A (0.41) | CYP2C19HTTSMN1; SMN2RAB9APDE11A | |
| SCHEMBL8287419 | 0.82 | PDE11A (0.51) | SMN1; SMN2PDE11AGAAALDH1A1KDM4E | |
| SCHEMBL8286365 | 0.80 | PDE11A (0.46) | HTTSMN1; SMN2RAB9APDE11AGAA | |
| SCHEMBL8286362 | 0.78 | PDE7A (0.43) | HTTPDE11AGAAALDH1A1KDM4E |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2005091857-A2 | 1,6-NAPHTHYRIDINE AND 1,8-NAPHTHYRIDINE DERIVATIVES AND THEIR USE TO TREAT DIABETES AND RELATED DISORDERS | BAYER PHARMACEUTICALS CORPORATION (US) | 2005-10-06 | — | — | WO | disclosed |
| WO-2003027112-A1 | 1, 8-NAPHTHYRIDINE DERIVATIVES AS ANTIDIABETICS | BAYER PHARMACEUTICALS CORPORATION (US) | 2003-04-03 | — | — | WO | disclosed |