Predicted protein targets (top 16)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | USP2 | O75604 | 2/20 | 0.46 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.46 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.46 |
| ▸ | MEN1 | O00255 | 1/20 | 0.46 |
| ▸ | HTT | P42858 | 1/20 | 0.46 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.46 |
| ▸ | PNP | P00491 | 1/20 | 0.43 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.41 |
| ▸ | RXFP1 | Q9HBX9 | 5/20 | 0.41 |
| ▸ | PDE11A | Q9HCR9 | 1/20 | 0.41 |
| ▸ | TLR4 | O00206 | 4/20 | 0.40 |
| ▸ | CCR5 | P51681 | 1/20 | 0.40 |
| ▸ | PKM | P14618 | 1/20 | 0.40 |
| ▸ | APOBEC3A | P31941 | 1/20 | 0.40 |
| ▸ | APOBEC3G | Q9HC16 | 1/20 | 0.40 |
| ▸ | GLA | P06280 | 1/20 | 0.39 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL8287463 | 0.88 | SMN1; SMN2 (0.48) | USP2ALDH1A1KDM4EHTTKMT2A | |
| SCHEMBL8361765 | 0.87 | GAA (0.45) | ALDH1A1KDM4ESMN1; SMN2PDE11A | |
| SCHEMBL8286356 | 0.87 | CYP3A4 (0.41) | USP2ALDH1A1KDM4EHTTPNP | |
| SCHEMBL5872280 | 0.84 | ALDH1A1 (0.46) | USP2ALDH1A1KDM4EMEN1HTT | |
| SCHEMBL8361763 | 0.83 | PDE11A (0.41) | USP2ALDH1A1KDM4EMEN1HTT | |
| SCHEMBL8286357 | 0.83 | ALDH1A1 (0.43) | USP2ALDH1A1KDM4EMEN1HTT | |
| SCHEMBL8286418 | 0.83 | LDHA (0.45) | ALDH1A1KDM4EMEN1HTTKMT2A | |
| SCHEMBL8286362 | 0.81 | PDE7A (0.43) | USP2ALDH1A1KDM4EMEN1HTT | |
| SCHEMBL8287419 | 0.81 | PDE11A (0.51) | USP2ALDH1A1KDM4EMEN1KMT2A | |
| SCHEMBL8286368 | 0.81 | PDE11A (0.44) | ALDH1A1KDM4EHTTSMN1; SMN2PDE11A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2005091857-A2 | 1,6-NAPHTHYRIDINE AND 1,8-NAPHTHYRIDINE DERIVATIVES AND THEIR USE TO TREAT DIABETES AND RELATED DISORDERS | BAYER PHARMACEUTICALS CORPORATION (US) | 2005-10-06 | — | — | WO | disclosed |
| WO-2003027112-A1 | 1, 8-NAPHTHYRIDINE DERIVATIVES AS ANTIDIABETICS | BAYER PHARMACEUTICALS CORPORATION (US) | 2003-04-03 | — | — | WO | disclosed |