Predicted protein targets (top 19)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | RAB9A | P51151 | 3/20 | 0.41 |
| ▸ | PDE11A | Q9HCR9 | 1/20 | 0.40 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.39 |
| ▸ | CSF1R | P07333 | 1/20 | 0.38 |
| ▸ | POLB | P06746 | 1/20 | 0.37 |
| ▸ | HTT | P42858 | 4/20 | 0.37 |
| ▸ | SMN1; SMN2 | Q16637 | 3/20 | 0.36 |
| ▸ | NPC1 | O15118 | 1/20 | 0.36 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.36 |
| ▸ | HCRTR1 | O43613 | 1/20 | 0.36 |
| ▸ | LMNA | P02545 | 1/20 | 0.36 |
| ▸ | ATM | Q13315 | 1/20 | 0.36 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.36 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.35 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.35 |
| ▸ | MAPT | P10636 | 1/20 | 0.35 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.35 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.35 |
| ▸ | UBE2N | P61088 | 1/20 | 0.35 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL8287417 | 0.91 | HTT (0.47) | RAB9APDE11AKDM4EHTTSMN1; SMN2 | |
| SCHEMBL8286366 | 0.90 | PDE11A (0.43) | PDE11AKDM4ECSF1RPOLBHTT | |
| SCHEMBL8286402 | 0.88 | ALDH1A1 (0.43) | RAB9APDE11AKDM4ECSF1RPOLB | |
| SCHEMBL8286418 | 0.87 | LDHA (0.45) | RAB9APDE11AKDM4EHTTALDH1A1 | |
| SCHEMBL8361762 | 0.83 | OPRK1 (0.41) | RAB9APDE11AKDM4ECSF1RPOLB | |
| SCHEMBL8286379 | 0.82 | PDE11A (0.43) | PDE11AKDM4EPOLBALDH1A1LMNA | |
| SCHEMBL8286356 | 0.82 | CYP3A4 (0.41) | RAB9APDE11AKDM4EPOLBHTT | |
| SCHEMBL8287532 | 0.82 | PDE11A (0.51) | PDE11AKDM4ESMN1; SMN2ALDH1A1LMNA | |
| SCHEMBL8287832 | 0.81 | PDE11A (0.47) | PDE11AKDM4EPOLBHTTSMN1; SMN2 | |
| SCHEMBL8286383 | 0.81 | PDE11A (0.51) | PDE11AKDM4ECSF1RPOLBHTT |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2005091857-A2 | 1,6-NAPHTHYRIDINE AND 1,8-NAPHTHYRIDINE DERIVATIVES AND THEIR USE TO TREAT DIABETES AND RELATED DISORDERS | BAYER PHARMACEUTICALS CORPORATION (US) | 2005-10-06 | — | — | WO | disclosed |
| WO-2003027112-A1 | 1, 8-NAPHTHYRIDINE DERIVATIVES AS ANTIDIABETICS | BAYER PHARMACEUTICALS CORPORATION (US) | 2003-04-03 | — | — | WO | disclosed |