Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ALDH1A1 | P00352 | 5/20 | 0.36 |
| ▸ | MAPT | P10636 | 6/20 | 0.36 |
| ▸ | TDP1 | Q9NUW8 | 2/20 | 0.36 |
| ▸ | POLB | P06746 | 1/20 | 0.36 |
| ▸ | KDM4E | B2RXH2 | 3/20 | 0.35 |
| ▸ | NPC1 | O15118 | 3/20 | 0.35 |
| ▸ | RAB9A | P51151 | 3/20 | 0.35 |
| ▸ | SMN1; SMN2 | Q16637 | 3/20 | 0.35 |
| ▸ | MAPK1 | P28482 | 2/20 | 0.35 |
| ▸ | RXFP1 | Q9HBX9 | 2/20 | 0.35 |
| ▸ | HPGD | P15428 | 1/20 | 0.35 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.35 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.35 |
| ▸ | GRM5 | P41594 | 1/20 | 0.35 |
| ▸ | LMNA | P02545 | 2/20 | 0.35 |
| ▸ | ALOX5 | P09917 | 1/20 | 0.35 |
| ▸ | PTGS2 | P35354 | 1/20 | 0.35 |
| ▸ | L3MBTL1 | Q9Y468 | 3/20 | 0.35 |
| ▸ | HPGDS | O60760 | 1/20 | 0.34 |
| ▸ | GAA | P10253 | 2/20 | 0.34 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL8287526 | 0.86 | MAPK13 (0.38) | MAPTKDM4ENPC1RAB9ASMN1; SMN2 | |
| SCHEMBL8286468 | 0.84 | GSK3B (0.38) | ALDH1A1MAPTPOLBKDM4ENPC1 | |
| SCHEMBL8287593 | 0.84 | GSK3B (0.37) | ALDH1A1MAPTNPC1RAB9ASMN1; SMN2 | |
| SCHEMBL8287205 | 0.83 | GSK3B (0.37) | PDE11A | |
| SCHEMBL8286472 | 0.81 | EGFR (0.46) | ALDH1A1MAPTPOLBKDM4ENPC1 | |
| SCHEMBL8285291 | 0.81 | GABRA1 (0.40) | ALDH1A1MAPTPOLBKDM4ENPC1 | |
| SCHEMBL8362924 | 0.80 | GSK3B (0.39) | ALDH1A1MAPTRAB9AMAPK1RXFP1 | |
| SCHEMBL8286508 | 0.80 | LOXL3 (0.42) | ALDH1A1TDP1POLBKDM4ESMN1; SMN2 | |
| SCHEMBL8287920 | 0.80 | CSF1R (0.37) | MAPTKDM4ENPC1RAB9ASMN1; SMN2 | |
| SCHEMBL8287968 | 0.79 | RIPK1 (0.41) | MAPTNPC1RAB9ARXFP1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2005091857-A2 | 1,6-NAPHTHYRIDINE AND 1,8-NAPHTHYRIDINE DERIVATIVES AND THEIR USE TO TREAT DIABETES AND RELATED DISORDERS | BAYER PHARMACEUTICALS CORPORATION (US) | 2005-10-06 | — | — | WO | disclosed |
| WO-2003027112-A1 | 1, 8-NAPHTHYRIDINE DERIVATIVES AS ANTIDIABETICS | BAYER PHARMACEUTICALS CORPORATION (US) | 2003-04-03 | — | — | WO | disclosed |