Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PDE11A | Q9HCR9 | 1/20 | 0.44 |
| ▸ | MAPK8 | P45983 | 2/20 | 0.40 |
| ▸ | MAPK9 | P45984 | 1/20 | 0.40 |
| ▸ | MEN1 | O00255 | 1/20 | 0.38 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.38 |
| ▸ | MAPK13 | O15264 | 1/20 | 0.38 |
| ▸ | MAPK12 | P53778 | 1/20 | 0.38 |
| ▸ | MAPK10 | P53779 | 1/20 | 0.38 |
| ▸ | MAPK11 | Q15759 | 1/20 | 0.38 |
| ▸ | MAPK14 | Q16539 | 1/20 | 0.38 |
| ▸ | CSNK2A1 | P68400 | 1/20 | 0.37 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.37 |
| ▸ | NPC1 | O15118 | 1/20 | 0.37 |
| ▸ | HPGD | P15428 | 1/20 | 0.37 |
| ▸ | MAT2A | P31153 | 1/20 | 0.36 |
| ▸ | CXCR4 | P61073 | 1/20 | 0.36 |
| ▸ | NPSR1 | Q6W5P4 | 3/20 | 0.35 |
| ▸ | KCNH2 | Q12809 | 1/20 | 0.35 |
| ▸ | MOK | Q9UQ07 | 1/20 | 0.35 |
| ▸ | TSHR | P16473 | 1/20 | 0.35 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL8287283 | 0.86 | PDE11A (0.34) | PDE11AHPGDMAT2ALMNAGAA | |
| SCHEMBL8287452 | 0.83 | PDE11A (0.55) | PDE11AMAPK8ALDH1A1NPC1MAT2A | |
| SCHEMBL8287611 | 0.82 | L3MBTL1 (0.36) | PDE11AALDH1A1NPC1HPGDMAT2A | |
| SCHEMBL8286150 | 0.81 | GSK3B (0.39) | PDE11AMEN1KMT2AMAPK13MAPK12 | |
| SCHEMBL8287617 | 0.81 | GSK3B (0.37) | PDE11AMEN1KMT2AALDH1A1HPGD | |
| SCHEMBL8286162 | 0.81 | GSK3B (0.37) | PDE11AALDH1A1HPGDMAT2AGAA | |
| SCHEMBL8286148 | 0.80 | GSK3B (0.36) | PDE11AMAPK8MAPK9MEN1KMT2A | |
| SCHEMBL8287455 | 0.80 | MAT2A (0.36) | PDE11AMAPK8MAPK9MEN1KMT2A | |
| SCHEMBL8287462 | 0.80 | PDE11A (0.44) | PDE11AALDH1A1HPGDNPSR1GAA | |
| SCHEMBL8287591 | 0.79 | LMNA (0.42) | PDE11ACSNK2A1ALDH1A1HPGDNPSR1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2005091857-A2 | 1,6-NAPHTHYRIDINE AND 1,8-NAPHTHYRIDINE DERIVATIVES AND THEIR USE TO TREAT DIABETES AND RELATED DISORDERS | BAYER PHARMACEUTICALS CORPORATION (US) | 2005-10-06 | — | — | WO | disclosed |
| WO-2003027112-A1 | 1, 8-NAPHTHYRIDINE DERIVATIVES AS ANTIDIABETICS | BAYER PHARMACEUTICALS CORPORATION (US) | 2003-04-03 | — | — | WO | disclosed |