Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | LMNA | P02545 | 1/20 | 0.42 |
| ▸ | PDE11A | Q9HCR9 | 1/20 | 0.42 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.41 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.41 |
| ▸ | HTT | P42858 | 1/20 | 0.41 |
| ▸ | ACHE | P22303 | 2/20 | 0.40 |
| ▸ | HSP90AA1 | P07900 | 1/20 | 0.40 |
| ▸ | HSP90AB1 | P08238 | 1/20 | 0.40 |
| ▸ | PTGS2 | P35354 | 1/20 | 0.39 |
| ▸ | TNK2 | Q07912 | 1/20 | 0.39 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.39 |
| ▸ | MAPT | P10636 | 2/20 | 0.38 |
| ▸ | GAA | P10253 | 1/20 | 0.38 |
| ▸ | HPGD | P15428 | 1/20 | 0.38 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.38 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.38 |
| ▸ | POLB | P06746 | 2/20 | 0.37 |
| ▸ | RXFP1 | Q9HBX9 | 1/20 | 0.37 |
| ▸ | MAP3K8 | P41279 | 1/20 | 0.37 |
| ▸ | SRC | P12931 | 1/20 | 0.37 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL8287514 | 0.86 | EGFR (0.42) | PDE11AMAPTGAASMN1; SMN2RAB9A | |
| SCHEMBL8287237 | 0.85 | PDE11A (0.43) | LMNAPDE11AALDH1A1KDM4EHSP90AA1 | |
| SCHEMBL8287462 | 0.83 | PDE11A (0.44) | PDE11AALDH1A1KDM4EMAPTGAA | |
| SCHEMBL8287483 | 0.83 | ADORA3 (0.45) | LMNAALDH1A1KDM4EMAPTHPGD | |
| SCHEMBL8287481 | 0.81 | MAT2A (0.49) | KDM4EHTTTNK2MAPK1GAA | |
| SCHEMBL8287565 | 0.80 | HTT (0.41) | ALDH1A1KDM4EHTTMAPTHPGD | |
| SCHEMBL8362929 | 0.79 | PIK3CA (0.44) | LMNAPDE11AMAPK1MAPTGAA | |
| SCHEMBL8287452 | 0.79 | PDE11A (0.55) | LMNAPDE11AALDH1A1KDM4EHTT | |
| SCHEMBL8362927 | 0.79 | MAT2A (0.44) | LMNAALDH1A1KDM4EHTTMAPT | |
| SCHEMBL8286576 | 0.79 | PDE11A (0.44) | LMNAPDE11AALDH1A1HTTTNK2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2005091857-A2 | 1,6-NAPHTHYRIDINE AND 1,8-NAPHTHYRIDINE DERIVATIVES AND THEIR USE TO TREAT DIABETES AND RELATED DISORDERS | BAYER PHARMACEUTICALS CORPORATION (US) | 2005-10-06 | — | — | WO | disclosed |
| WO-2003027112-A1 | 1, 8-NAPHTHYRIDINE DERIVATIVES AS ANTIDIABETICS | BAYER PHARMACEUTICALS CORPORATION (US) | 2003-04-03 | — | — | WO | disclosed |