Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CHRNB2 | P17787 | 3/20 | 0.38 |
| ▸ | CHRNA4 | P43681 | 3/20 | 0.38 |
| ▸ | CHRM2 | P08172 | 2/20 | 0.38 |
| ▸ | CHRM1 | P11229 | 2/20 | 0.38 |
| ▸ | CHRM3 | P20309 | 2/20 | 0.38 |
| ▸ | SLC6A4 | P31645 | 3/20 | 0.35 |
| ▸ | SLC6A2 | P23975 | 2/20 | 0.35 |
| ▸ | SLC6A3 | Q01959 | 2/20 | 0.35 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.35 |
| ▸ | CTSL | P07711 | 1/20 | 0.34 |
| ▸ | EED | O75530 | 1/20 | 0.34 |
| ▸ | PDE4A | P27815 | 3/20 | 0.34 |
| ▸ | PDE4B | Q07343 | 3/20 | 0.34 |
| ▸ | PDE4C | Q08493 | 3/20 | 0.34 |
| ▸ | PDE4D | Q08499 | 3/20 | 0.34 |
| ▸ | TP53 | P04637 | 2/20 | 0.34 |
| ▸ | MAPT | P10636 | 1/20 | 0.34 |
| ▸ | GPBAR1 | Q8TDU6 | 1/20 | 0.33 |
| ▸ | PTAFR | P25105 | 1/20 | 0.31 |
| ▸ | MEN1 | O00255 | 1/20 | 0.31 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL8284774 | 0.90 | SLC6A4 (0.35) | CHRNB2CHRNA4CHRM2CHRM1CHRM3 | |
| SCHEMBL8284814 | 0.90 | CTSL (0.41) | CTSLPDE4APDE4BPDE4CPDE4D | |
| SCHEMBL2908516 | 0.85 | CHRNB2 (0.40) | CHRNB2CHRNA4CHRM2CHRM1CHRM3 | |
| SCHEMBL8284044 | 0.82 | KMT2A (0.40) | CHRNB2CHRNA4CTSLPDE4APDE4B | |
| SCHEMBL8285836 | 0.81 | GPBAR1 (0.38) | CHRNB2CHRNA4CTSLTP53MAPT | |
| SCHEMBL8284052 | 0.80 | PDE4A (0.38) | PDE4APDE4BPDE4CPDE4DTP53 | |
| SCHEMBL8286587 | 0.80 | L3MBTL1 (0.42) | PDE4APDE4BPDE4CPDE4DMEN1 | |
| SCHEMBL8284045 | 0.79 | KMT2A (0.41) | PDE4APDE4BPDE4CPDE4DGPBAR1 | |
| SCHEMBL2909468 | 0.78 | PDE4A (0.45) | CHRNB2CHRNA4CHRM2CHRM1CHRM3 | |
| SCHEMBL8284049 | 0.77 | PTGER2 (0.38) | PDE4APDE4BPDE4CPDE4DTP53 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2005061458-A2 | PHOSPHODIESTERASE 4 INHIBITORS, INCLUDING N-SUBSTITUTED DIARYLAMINE ANALOGS | MEMORY PHARMACEUTICALS CORPORATION (US) | 2005-07-07 | — | — | WO | disclosed |