Predicted protein targets (top 17)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MAT2A | P31153 | 4/20 | 0.49 |
| ▸ | MAPK1 | P28482 | 4/20 | 0.39 |
| ▸ | ADORA3 | P0DMS8 | 3/20 | 0.38 |
| ▸ | ADORA1 | P30542 | 3/20 | 0.38 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.35 |
| ▸ | HTT | P42858 | 1/20 | 0.35 |
| ▸ | CSF1R | P07333 | 1/20 | 0.34 |
| ▸ | SYK | P43405 | 1/20 | 0.34 |
| ▸ | TNK2 | Q07912 | 1/20 | 0.34 |
| ▸ | GSK3B | P49841 | 1/20 | 0.34 |
| ▸ | PIK3CA | P42336 | 1/20 | 0.34 |
| ▸ | PRKDC | P78527 | 1/20 | 0.34 |
| ▸ | EGFR | P00533 | 1/20 | 0.34 |
| ▸ | TSPO | P30536 | 1/20 | 0.34 |
| ▸ | GAA | P10253 | 2/20 | 0.33 |
| ▸ | GFER | P55789 | 1/20 | 0.33 |
| ▸ | HPGD | P15428 | 1/20 | 0.33 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL8287514 | 0.89 | EGFR (0.42) | MAT2AADORA3ADORA1GSK3BPIK3CA | |
| SCHEMBL8287565 | 0.87 | HTT (0.41) | MAT2AADORA3ADORA1KDM4EHTT | |
| SCHEMBL8287483 | 0.86 | ADORA3 (0.45) | MAT2AADORA3ADORA1KDM4EEGFR | |
| SCHEMBL8287923 | 0.83 | MAT2A (0.41) | MAT2AMAPK1CSF1RTNK2GSK3B | |
| SCHEMBL8362929 | 0.82 | PIK3CA (0.44) | MAT2AMAPK1ADORA3ADORA1GSK3B | |
| SCHEMBL8287236 | 0.82 | MAT2A (0.40) | MAT2AMAPK1KDM4ETNK2EGFR | |
| SCHEMBL8362927 | 0.82 | MAT2A (0.44) | MAT2AADORA3ADORA1KDM4EHTT | |
| SCHEMBL8287591 | 0.81 | LMNA (0.42) | MAPK1KDM4EHTTTNK2GAA | |
| SCHEMBL8286470 | 0.80 | KCNH3 (0.40) | MAPK1KDM4EGSK3BPIK3CAPRKDC | |
| SCHEMBL8286451 | 0.80 | RAB9A (0.36) | MAT2AADORA3ADORA1KDM4EGSK3B |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2005091857-A2 | 1,6-NAPHTHYRIDINE AND 1,8-NAPHTHYRIDINE DERIVATIVES AND THEIR USE TO TREAT DIABETES AND RELATED DISORDERS | BAYER PHARMACEUTICALS CORPORATION (US) | 2005-10-06 | — | — | WO | disclosed |
| WO-2003027112-A1 | 1, 8-NAPHTHYRIDINE DERIVATIVES AS ANTIDIABETICS | BAYER PHARMACEUTICALS CORPORATION (US) | 2003-04-03 | — | — | WO | disclosed |