Predicted protein targets (top 18)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ALDH1A1 | P00352 | 8/20 | 0.46 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.46 |
| ▸ | HPGD | P15428 | 4/20 | 0.43 |
| ▸ | LMNA | P02545 | 1/20 | 0.43 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.42 |
| ▸ | PKM | P14618 | 1/20 | 0.42 |
| ▸ | POLB | P06746 | 3/20 | 0.41 |
| ▸ | TSHR | P16473 | 2/20 | 0.41 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.41 |
| ▸ | TP53 | P04637 | 1/20 | 0.41 |
| ▸ | RAB9A | P51151 | 1/20 | 0.40 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.40 |
| ▸ | GAA | P10253 | 2/20 | 0.40 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.40 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.40 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.40 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.40 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.40 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL8286498 | 0.88 | GAA (0.47) | ALDH1A1HPGDLMNAPOLBTSHR | |
| SCHEMBL8287235 | 0.85 | NPC1 (0.49) | ALDH1A1KMT2ALMNAPKMPOLB | |
| SCHEMBL8287236 | 0.83 | MAT2A (0.40) | ALDH1A1KMT2ALMNAL3MBTL1TSHR | |
| SCHEMBL8287943 | 0.83 | NPC1 (0.40) | ALDH1A1KMT2AHPGDLMNAPKM | |
| SCHEMBL8285265 | 0.82 | ALDH1A1 (0.46) | ALDH1A1KMT2AHPGDLMNAL3MBTL1 | |
| SCHEMBL8286471 | 0.81 | PDE7A (0.38) | ALDH1A1KMT2AHPGDLMNARAB9A | |
| SCHEMBL8287515 | 0.81 | BCL6 (0.40) | ALDH1A1KMT2AHPGDLMNAPOLB | |
| SCHEMBL8285328 | 0.79 | GSK3B (0.38) | ALDH1A1KMT2AHPGDLMNASMN1; SMN2 | |
| SCHEMBL8286467 | 0.76 | PDE11A (0.44) | ALDH1A1LMNAPOLBSMN1; SMN2GAA | |
| SCHEMBL8285284 | 0.76 | CKS1B (0.45) | KMT2A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2005091857-A2 | 1,6-NAPHTHYRIDINE AND 1,8-NAPHTHYRIDINE DERIVATIVES AND THEIR USE TO TREAT DIABETES AND RELATED DISORDERS | BAYER PHARMACEUTICALS CORPORATION (US) | 2005-10-06 | — | — | WO | disclosed |
| WO-2003027112-A1 | 1, 8-NAPHTHYRIDINE DERIVATIVES AS ANTIDIABETICS | BAYER PHARMACEUTICALS CORPORATION (US) | 2003-04-03 | — | — | WO | disclosed |