Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | RAB9A | P51151 | 3/20 | 0.43 |
| ▸ | ALDH1A1 | P00352 | 4/20 | 0.33 |
| ▸ | CYP1A2 | P05177 | 2/20 | 0.33 |
| ▸ | NPC1 | O15118 | 1/20 | 0.33 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.33 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.33 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.33 |
| ▸ | PDE11A | Q9HCR9 | 1/20 | 0.33 |
| ▸ | GAA | P10253 | 1/20 | 0.33 |
| ▸ | HPGD | P15428 | 1/20 | 0.33 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.33 |
| ▸ | KDM4E | B2RXH2 | 3/20 | 0.32 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.32 |
| ▸ | MAPT | P10636 | 1/20 | 0.32 |
| ▸ | DHFR | P00374 | 2/20 | 0.32 |
| ▸ | MEN1 | O00255 | 3/20 | 0.31 |
| ▸ | KMT2A | Q03164 | 3/20 | 0.31 |
| ▸ | HTT | P42858 | 1/20 | 0.31 |
| ▸ | CDK4 | P11802 | 1/20 | 0.31 |
| ▸ | CCND1 | P24385 | 1/20 | 0.31 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL8287246 | 0.85 | GAA (0.39) | ALDH1A1CYP3A4SMN1; SMN2PDE11AGAA | |
| SCHEMBL8287276 | 0.85 | MAT2A (0.40) | RAB9ASMN1; SMN2GAAHPGDMAPK1 | |
| SCHEMBL8286178 | 0.85 | GAA (0.36) | RAB9AALDH1A1NPC1SMN1; SMN2PDE11A | |
| SCHEMBL8286211 | 0.83 | MAP3K8 (0.34) | PDE11AGAAHPGDMAPK1KDM4E | |
| SCHEMBL8286173 | 0.82 | GAA (0.36) | RAB9AALDH1A1CYP1A2NPC1CYP3A4 | |
| SCHEMBL8286182 | 0.81 | MAT2A (0.46) | ALDH1A1SMN1; SMN2PDE11AGAAHPGD | |
| SCHEMBL8286174 | 0.80 | BRAF (0.39) | RAB9AALDH1A1NPC1CYP3A4CYP2C19 | |
| SCHEMBL8286184 | 0.79 | ALDH1A1 (0.39) | RAB9AALDH1A1GAAMAPTKMT2A | |
| SCHEMBL8285360 | 0.78 | MAPT (0.41) | ALDH1A1PDE11AGAAHPGDMAPK1 | |
| SCHEMBL8287251 | 0.78 | GAA (0.36) | ALDH1A1SMN1; SMN2PDE11AGAAHPGD |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2005091857-A2 | 1,6-NAPHTHYRIDINE AND 1,8-NAPHTHYRIDINE DERIVATIVES AND THEIR USE TO TREAT DIABETES AND RELATED DISORDERS | BAYER PHARMACEUTICALS CORPORATION (US) | 2005-10-06 | — | — | WO | disclosed |
| WO-2003027112-A1 | 1, 8-NAPHTHYRIDINE DERIVATIVES AS ANTIDIABETICS | BAYER PHARMACEUTICALS CORPORATION (US) | 2003-04-03 | — | — | WO | disclosed |