Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HTT | P42858 | 2/20 | 0.41 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.41 |
| ▸ | CSF1R | P07333 | 1/20 | 0.41 |
| ▸ | ADORA1 | P30542 | 2/20 | 0.38 |
| ▸ | ADORA3 | P0DMS8 | 1/20 | 0.38 |
| ▸ | ELANE | P08246 | 1/20 | 0.38 |
| ▸ | ALDH1A1 | P00352 | 6/20 | 0.38 |
| ▸ | SMN1; SMN2 | Q16637 | 4/20 | 0.38 |
| ▸ | HPGD | P15428 | 3/20 | 0.38 |
| ▸ | TP53 | P04637 | 1/20 | 0.38 |
| ▸ | POLB | P06746 | 1/20 | 0.38 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.38 |
| ▸ | MEN1 | O00255 | 2/20 | 0.37 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.37 |
| ▸ | MAPT | P10636 | 2/20 | 0.37 |
| ▸ | RAB9A | P51151 | 2/20 | 0.37 |
| ▸ | NPC1 | O15118 | 1/20 | 0.37 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.37 |
| ▸ | TSHR | P16473 | 1/20 | 0.37 |
| ▸ | MAT2A | P31153 | 2/20 | 0.37 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL8287514 | 0.87 | EGFR (0.42) | ADORA1ADORA3SMN1; SMN2MAPTRAB9A | |
| SCHEMBL8287481 | 0.87 | MAT2A (0.49) | HTTKDM4ECSF1RADORA1ADORA3 | |
| SCHEMBL8287483 | 0.85 | ADORA3 (0.45) | KDM4EADORA1ADORA3ALDH1A1HPGD | |
| SCHEMBL8287248 | 0.84 | MEN1 (0.43) | HTTKDM4ECSF1RALDH1A1SMN1; SMN2 | |
| SCHEMBL8287930 | 0.83 | CSF1R (0.47) | HTTKDM4ECSF1RADORA3ALDH1A1 | |
| SCHEMBL8285265 | 0.83 | ALDH1A1 (0.46) | CSF1RALDH1A1SMN1; SMN2HPGDTP53 | |
| SCHEMBL8286470 | 0.81 | KCNH3 (0.40) | KDM4EALDH1A1 | |
| SCHEMBL8362929 | 0.81 | PIK3CA (0.44) | ADORA1ADORA3HPGDMEN1KMT2A | |
| SCHEMBL8362927 | 0.80 | MAT2A (0.44) | HTTKDM4EADORA1ADORA3ALDH1A1 | |
| SCHEMBL8287591 | 0.80 | LMNA (0.42) | HTTKDM4EALDH1A1SMN1; SMN2HPGD |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2005091857-A2 | 1,6-NAPHTHYRIDINE AND 1,8-NAPHTHYRIDINE DERIVATIVES AND THEIR USE TO TREAT DIABETES AND RELATED DISORDERS | BAYER PHARMACEUTICALS CORPORATION (US) | 2005-10-06 | — | — | WO | disclosed |
| WO-2003027112-A1 | 1, 8-NAPHTHYRIDINE DERIVATIVES AS ANTIDIABETICS | BAYER PHARMACEUTICALS CORPORATION (US) | 2003-04-03 | — | — | WO | disclosed |