Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PKM | P14618 | 3/20 | 0.49 |
| ▸ | TRIM24 | O15164 | 2/20 | 0.49 |
| ▸ | GAA | P10253 | 2/20 | 0.48 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.48 |
| ▸ | SMYD3 | Q9H7B4 | 1/20 | 0.47 |
| ▸ | BMPR1B | O00238 | 2/20 | 0.46 |
| ▸ | BMPR1A | P36894 | 2/20 | 0.46 |
| ▸ | ACVRL1 | P37023 | 2/20 | 0.46 |
| ▸ | ACVR1 | Q04771 | 2/20 | 0.46 |
| ▸ | DRD2 | P14416 | 2/20 | 0.44 |
| ▸ | DRD1 | P21728 | 2/20 | 0.44 |
| ▸ | DRD5 | P21918 | 2/20 | 0.44 |
| ▸ | DRD3 | P35462 | 2/20 | 0.44 |
| ▸ | LMNA | P02545 | 3/20 | 0.44 |
| ▸ | POLB | P06746 | 2/20 | 0.44 |
| ▸ | MEN1 | O00255 | 1/20 | 0.44 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.44 |
| ▸ | IDO1 | P14902 | 1/20 | 0.44 |
| ▸ | TGFBR1 | P36897 | 1/20 | 0.43 |
| ▸ | DRD4 | P21917 | 1/20 | 0.42 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL30667271 | 1.00 | PKM (0.49) | PKMTRIM24GAAALDH1A1SMYD3 | |
| SCHEMBL31104373 | 0.85 | DRD2 (0.44) | PKMTRIM24GAAALDH1A1SMYD3 | |
| SCHEMBL11032224 | 0.85 | DRD2 (0.44) | PKMTRIM24GAAALDH1A1SMYD3 | |
| SCHEMBL6073575 | 0.84 | CYP11B2 (0.51) | TRIM24DRD2DRD1DRD5DRD3 | |
| SCHEMBL29853611 | 0.83 | HSD17B1 (0.47) | DRD2DRD1DRD5DRD3DRD4 | |
| SCHEMBL26768759 | 0.83 | HSD17B1 (0.47) | DRD2DRD1DRD5DRD3DRD4 | |
| SCHEMBL1925311 | 0.81 | PKM (0.59) | PKMTRIM24GAAALDH1A1SMYD3 | |
| SCHEMBL19980481 | 0.81 | MAOA (0.49) | BMPR1BBMPR1AACVRL1ACVR1DRD2 | |
| SCHEMBL434054 | 0.79 | TRIM24 (0.54) | PKMTRIM24GAAALDH1A1SMYD3 | |
| SCHEMBL30222138 | 0.79 | TRIM24 (0.54) | PKMTRIM24GAAALDH1A1SMYD3 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 10 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2005041957-A1 | OXINDOLE DERIVATIVES AND THEIR USE AS PHOSPHODIESTERASE TYPE 2 INHIBITORS | PFIZER PRODUCTS INC. (US) | 2005-05-12 | — | — | WO | disclosed |
| WO-1992007830-A2 | OXINDOLE PEPTIDE ANTAGONISTS | PFIZER INC. (US) | 1992-05-14 | — | — | WO | disclosed |
| US-4695571-A | Tricyclic oxindole antiinflammatory agents | PFIZER INC. (US) | 1987-09-22 | — | — | US | disclosed |
| WO-1986001510-A1 | TRICYCLIC OXINDOLE ANTIINFLAMMATORY AGENTS | PFIZER INC. (US) | 1986-03-13 | — | — | WO | disclosed |
| US-4313947-A | TREATMENT OF BLOOD DISORDERS | OTSUKA PHARMACEUTICAL CO., LTD. (JP) | 1982-02-02 | — | — | US | disclosed |
| EP-0005828-B1 | NEW SUBSTITUTED PHENYLPIPERAZINE DERIVATIVES, PHARMACEUTICAL COMPOSITIONS CONTAINING THEM AND PROCESS FOR THEIR PREPARATION | HOECHST AKTIENGESELLSCHAFT (DE) | 1981-03-11 | — | — | EP | disclosed |
| US-4234584-A | NEUROLEPTIC | HOECHST AKTIENGESELLSCHAFT (DE) | 1980-11-18 | — | — | US | disclosed |
| US-4216220-A | Platelet aggregation inhibiting 2-oxyindoles, their compositions and method of use | OTSUKA PHARMACEUTICAL CO., LTD. (JP) | 1980-08-05 | — | — | US | disclosed |
| EP-0005828-A1 | New substituted phenylpiperazine derivatives, pharmaceutical compositions containing them and process for their preparation | HOECHST AKTIENGESELLSCHAFT (DE) | 1979-12-12 | — | — | EP | disclosed |
| US-4070470-A | BENCYCLOAMIDE DERIVATIVES | OTSUKA PHARMACEUTICAL CO., LTD. (JA) | 1978-01-24 | — | — | US | disclosed |