Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | BCHE | P06276 | 1/20 | 0.45 |
| ▸ | ACHE | P22303 | 1/20 | 0.45 |
| ▸ | MAOA | P21397 | 1/20 | 0.45 |
| ▸ | MAOB | P27338 | 1/20 | 0.45 |
| ▸ | HTR2C | P28335 | 3/20 | 0.34 |
| ▸ | CYP1A2 | P05177 | 2/20 | 0.34 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.34 |
| ▸ | MEN1 | O00255 | 1/20 | 0.34 |
| ▸ | NPC1 | O15118 | 1/20 | 0.34 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.34 |
| ▸ | PKM | P14618 | 1/20 | 0.34 |
| ▸ | HPGD | P15428 | 1/20 | 0.34 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.34 |
| ▸ | RAB9A | P51151 | 1/20 | 0.34 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.34 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.34 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.34 |
| ▸ | CRBN | Q96SW2 | 1/20 | 0.34 |
| ▸ | ADORA2A | P29274 | 2/20 | 0.32 |
| ▸ | CYP1A1 | P04798 | 1/20 | 0.32 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL8290904 | 0.81 | ACHE (0.46) | BCHEACHEMAOAMAOBCYP1A2 | |
| SCHEMBL10906155 | 0.74 | MAOA (0.56) | BCHEACHEMAOAMAOBHTR2C | |
| SCHEMBL8300839 | 0.73 | ASAH1 (0.37) | BCHEACHEHTR2CCYP1A2KDM4E | |
| SCHEMBL2593078 | 0.70 | BCHE (0.59) | BCHEACHEMAOAMAOBHTR2C | |
| SCHEMBL28792307 | 0.64 | SLC6A2 (0.53) | CYP1A2KDM4EMEN1NPC1ALDH1A1 | |
| SCHEMBL29876774 | 0.64 | SLC6A2 (0.53) | CYP1A2KDM4EMEN1NPC1ALDH1A1 | |
| SCHEMBL721717 | 0.64 | ACHE (1.00) | BCHEACHEMAOAMAOBSLC6A2 | |
| SCHEMBL2090835 | 0.64 | SIGMAR1 (0.61) | ALDH1A1HSD17B10 | |
| Citric Acid SCHEMBL7968886 | 0.63 | BCHE (0.41) | BCHEACHEMAOAMAOBHTR2C | |
| SCHEMBL28792227 | 0.63 | MAOA (0.44) | BCHEACHEMAOAMAOBCYP1A2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-5708007-A | ACETYLCHOLINESTERASE INHIBITORS | HOECHST MARION ROUSSEL, INC. (US) | 1998-01-13 | — | — | US | claimed |
| EP-0637586-B1 | 2-(Piperidin-4-yl, pyridin-4-yl and tetrahydropyridin-4-yl)-benzofuran-7-carbamate derivatives, their preparation and their use as acetylcholinesterase inhibitors | HOECHST MARION ROUSSEL INC (US) | 1999-06-02 | — | — | EP | disclosed |
| US-5708007-A | ACETYLCHOLINESTERASE INHIBITORS | HOECHST MARION ROUSSEL, INC. (US) | 1998-01-13 | — | — | US | disclosed |
| EP-0637586-A1 | 2-(Piperidin-4-yl, pyridin-4-yl and tetrahydropyridin-4-yl)benzofuran-7-ol and carbamate derivatives, their preparation and their use as acetylcholinesterase inhibitors | HOECHST-ROUSSEL PHARMACEUTICALS INCORPORATED (US) | 1995-02-08 | — | — | EP | disclosed |