Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | LRRK2 | Q5S007 | 1/20 | 0.33 |
| ▸ | IKBKB | O14920 | 1/20 | 0.33 |
| ▸ | KDM4E | B2RXH2 | 4/20 | 0.33 |
| ▸ | SMN1; SMN2 | Q16637 | 4/20 | 0.33 |
| ▸ | ALDH1A1 | P00352 | 4/20 | 0.33 |
| ▸ | NPC1 | O15118 | 2/20 | 0.33 |
| ▸ | RAB9A | P51151 | 2/20 | 0.33 |
| ▸ | MAPT | P10636 | 2/20 | 0.33 |
| ▸ | HSD17B10 | Q99714 | 2/20 | 0.33 |
| ▸ | TP53 | P04637 | 1/20 | 0.33 |
| ▸ | NFKB1 | P19838 | 1/20 | 0.33 |
| ▸ | NFKB2 | Q00653 | 1/20 | 0.33 |
| ▸ | RELA | Q04206 | 1/20 | 0.33 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.33 |
| ▸ | ICMT | O60725 | 1/20 | 0.32 |
| ▸ | AAK1 | Q2M2I8 | 1/20 | 0.32 |
| ▸ | MEN1 | O00255 | 2/20 | 0.31 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.31 |
| ▸ | ABL1 | P00519 | 1/20 | 0.31 |
| ▸ | BCR | P11274 | 1/20 | 0.31 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL8293186 | 0.88 | HSD17B10 (0.44) | IKBKBKDM4ESMN1; SMN2ALDH1A1NPC1 | |
| SCHEMBL8293154 | 0.79 | KCNH2 (0.53) | — | |
| SCHEMBL16298594 | 0.73 | GAA (0.41) | KDM4ESMN1; SMN2ALDH1A1MAPTHSD17B10 | |
| SCHEMBL8348073 | 0.73 | FDPS (0.46) | KDM4ESMN1; SMN2ALDH1A1CYP3A4TSHR | |
| SCHEMBL13809208 | 0.70 | CASP1 (0.41) | KDM4ESMN1; SMN2ALDH1A1NPC1RAB9A | |
| SCHEMBL13078449 | 0.70 | ESR1 (0.43) | KDM4ESMN1; SMN2ALDH1A1NPC1RAB9A | |
| SCHEMBL15508767 | 0.69 | PRKCI (0.38) | KDM4ESMN1; SMN2ALDH1A1NPC1RAB9A | |
| SCHEMBL15463057 | 0.67 | ACHE (0.43) | KDM4EALDH1A1MAPTL3MBTL1MEN1 | |
| SCHEMBL13652200 | 0.66 | KDM5A (0.35) | — | |
| SCHEMBL5953299 | 0.65 | TDP1 (0.70) | KDM4ESMN1; SMN2ALDH1A1NPC1RAB9A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2005030704-A1 | INHIBITORS OF HISTONE DEACETYLASE | METHYLGENE, INC. (CA) | 2005-04-07 | — | — | WO | disclosed |