SCHEMBL8295083

SCHEMBL8295083

O=C(O)C1CNC(=O)C1Cc1ccccc1

nearest known ligand 0.44

Predicted protein targets (top 14)

geneUniProtsupporting neighboursconfidence
CTRB1 P17538 1/20 0.41
MC4R P32245 1/20 0.41
F2 P00734 2/20 0.40
PRSS1 P07477 2/20 0.40
CYP19A1 P11511 1/20 0.40
HDAC8 Q9BY41 2/20 0.40
DDB1 Q16531 1/20 0.40
CRBN Q96SW2 1/20 0.40
FASN P49327 1/20 0.40
NAAA Q02083 3/20 0.39
LMNA P02545 1/20 0.39
TSHR P16473 1/20 0.38
HSD17B10 Q99714 1/20 0.38
GBA1 P04062 1/20 0.37

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL20875887 1.00 CTRB1 (0.41) CTRB1MC4RF2PRSS1CYP19A1
SCHEMBL20875888 1.00 CTRB1 (0.41) CTRB1MC4RF2PRSS1CYP19A1
SCHEMBL20875936 0.88 CTRB1 (0.39) CTRB1MC4RF2PRSS1CYP19A1
SCHEMBL20875907 0.86 SMN1; SMN2 (0.42)
SCHEMBL20875905 0.86 SMN1; SMN2 (0.42)
SCHEMBL22279740 0.84 NAAA (0.41) MC4RNAAATSHRHSD17B10
SCHEMBL20875895 0.84 NAAA (0.41) MC4RNAAATSHRHSD17B10
SCHEMBL22279878 0.82 PKM (0.46) NAAATSHR
SCHEMBL22279804 0.82 PKM (0.46) NAAATSHR
SCHEMBL20875984 0.81 NAAA (0.43) NAAA

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 5 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
US-11180479-B2 Antiviral compounds HAPLOGEN GMBH (AT) 2021-11-23 US disclosed
EP-3692035-A1 ANTIVIRAL COMPOUNDS Haplogen GmbH (AT) 2020-08-12 EP disclosed
US-20200239446-A1 ANTIVIRAL COMPOUNDS LUNIS CONSULTING GMBH (AT) 2020-07-30 US disclosed
WO-2019068841-A1 ANTIVIRAL COMPOUNDS HAPLOGEN GMBH (AT) 2019-04-11 WO disclosed
WO-2005014540-A1 CYCLIC AMINE BASE-1 INHIBITORS HAVING A HETEROCYCLIC SUBSTITUENT SCHERING CORPORATION (US) 2005-02-17 WO disclosed

Patent text — is the patent's own abstract consistent with the prediction?

For each of this compound's patents that has machine-readable text (2 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.

PatentTitleText reads most aboutPredicted target · text-rank
US-11180479-B2 Antiviral compounds PLA2G1B, PLA2G4A, PLA2G4C CTRB1 663/4885MC4R 3452/4885F2 1693/4885
US-20200239446-A1 ANTIVIRAL COMPOUNDS PLA2G1B, PLA2G4A, PLA2G4C CTRB1 663/4885MC4R 3452/4885F2 1693/4885

“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.