Predicted protein targets (top 17)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ABL1 | P00519 | 2/20 | 0.38 |
| ▸ | KCNH2 | Q12809 | 1/20 | 0.38 |
| ▸ | KDR | P35968 | 2/20 | 0.38 |
| ▸ | LCLAT1 | Q6UWP7 | 3/20 | 0.36 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.36 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.35 |
| ▸ | GPR6 | P46095 | 1/20 | 0.35 |
| ▸ | PDCD1 | Q15116 | 1/20 | 0.35 |
| ▸ | CD274 | Q9NZQ7 | 1/20 | 0.35 |
| ▸ | RUNX1 | Q01196 | 1/20 | 0.35 |
| ▸ | FOXO1 | Q12778 | 1/20 | 0.35 |
| ▸ | WNT3A | P56704 | 1/20 | 0.34 |
| ▸ | PDE4B | Q07343 | 1/20 | 0.34 |
| ▸ | AURKA | O14965 | 1/20 | 0.34 |
| ▸ | JAK2 | O60674 | 1/20 | 0.34 |
| ▸ | JAK3 | P52333 | 1/20 | 0.34 |
| ▸ | FGFR3 | P22607 | 1/20 | 0.34 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL8305625 | 0.87 | GAA (0.40) | ALDH1A1PDCD1CD274 | |
| SCHEMBL8305570 | 0.86 | CNR2 (0.39) | ABL1KCNH2WNT3A | |
| SCHEMBL12303916 | 0.82 | KCNH2 (0.42) | ABL1KCNH2KDRALDH1A1RUNX1 | |
| SCHEMBL8302364 | 0.81 | HIF1A (0.47) | ALDH1A1CD274AURKA | |
| SCHEMBL16471209 | 0.78 | MAPK14 (0.39) | ALDH1A1KMT2A | |
| SCHEMBL8305595 | 0.78 | PARP1 (0.34) | KCNH2ALDH1A1GPR6PDCD1CD274 | |
| SCHEMBL8300908 | 0.77 | MAPT (0.36) | PDCD1CD274AURKAJAK2JAK3 | |
| SCHEMBL8306105 | 0.76 | PKM (0.40) | KCNH2ALDH1A1 | |
| SCHEMBL13545093 | 0.76 | AURKA (0.41) | ABL1KCNH2KDRKMT2AAURKA | |
| SCHEMBL8299878 | 0.75 | NPC1 (0.42) | ABL1KMT2AAURKA |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2005002552-A2 | BENZIMIDAZOLE DERIVATIVES AND THEIR USE AS PROTEIN KINASES INHIBITORS | ASTEX THERAPEUTICS LIMITED (GB) | 2005-01-13 | — | — | WO | disclosed |