Predicted protein targets (top 15)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | GAA | P10253 | 2/20 | 0.40 |
| ▸ | MAPK1 | P28482 | 2/20 | 0.40 |
| ▸ | BRPF1 | P55201 | 1/20 | 0.40 |
| ▸ | POLB | P06746 | 1/20 | 0.40 |
| ▸ | ALDH1A1 | P00352 | 5/20 | 0.40 |
| ▸ | STAT3 | P40763 | 1/20 | 0.40 |
| ▸ | MAPT | P10636 | 2/20 | 0.39 |
| ▸ | ALOX15 | P16050 | 1/20 | 0.39 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.39 |
| ▸ | BCL3 | P20749 | 2/20 | 0.39 |
| ▸ | PDCD1 | Q15116 | 1/20 | 0.38 |
| ▸ | CD274 | Q9NZQ7 | 1/20 | 0.38 |
| ▸ | TSHR | P16473 | 3/20 | 0.38 |
| ▸ | HCN4 | Q9Y3Q4 | 1/20 | 0.38 |
| ▸ | BCHE | P06276 | 1/20 | 0.38 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL8305570 | 0.90 | CNR2 (0.39) | BCL3 | |
| SCHEMBL8299902 | 0.87 | ABL1 (0.38) | ALDH1A1PDCD1CD274 | |
| SCHEMBL8305595 | 0.86 | PARP1 (0.34) | GAAPOLBALDH1A1MAPTSMN1; SMN2 | |
| SCHEMBL8300908 | 0.84 | MAPT (0.36) | MAPTSMN1; SMN2PDCD1CD274TSHR | |
| SCHEMBL8306105 | 0.84 | PKM (0.40) | GAAALDH1A1MAPTSMN1; SMN2BCL3 | |
| SCHEMBL8302364 | 0.82 | HIF1A (0.47) | GAAPOLBALDH1A1STAT3MAPT | |
| SCHEMBL16471209 | 0.81 | MAPK14 (0.39) | MAPK1ALDH1A1MAPTSMN1; SMN2TSHR | |
| SCHEMBL8299878 | 0.80 | NPC1 (0.42) | MAPK1MAPTSMN1; SMN2 | |
| SCHEMBL8302374 | 0.80 | KDM4E (0.34) | — | |
| SCHEMBL14311682 | 0.80 | AURKA (0.43) | GAAPOLBSMN1; SMN2TSHR |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2005002552-A2 | BENZIMIDAZOLE DERIVATIVES AND THEIR USE AS PROTEIN KINASES INHIBITORS | ASTEX THERAPEUTICS LIMITED (GB) | 2005-01-13 | — | — | WO | disclosed |