Predicted protein targets (top 14)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | SLC6A2 | P23975 | 10/20 | 0.54 |
| ▸ | SLC6A4 | P31645 | 10/20 | 0.54 |
| ▸ | SLC6A3 | Q01959 | 6/20 | 0.54 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.51 |
| ▸ | TACR1 | P25103 | 3/20 | 0.46 |
| ▸ | NPFFR1 | Q9GZQ6 | 1/20 | 0.43 |
| ▸ | NPFFR2 | Q9Y5X5 | 1/20 | 0.43 |
| ▸ | CCR5 | P51681 | 2/20 | 0.43 |
| ▸ | CCR3 | P51677 | 1/20 | 0.43 |
| ▸ | PRMT3 | O60678 | 1/20 | 0.42 |
| ▸ | CARM1 | Q86X55 | 1/20 | 0.42 |
| ▸ | PRMT6 | Q96LA8 | 1/20 | 0.42 |
| ▸ | PRMT1 | Q99873 | 1/20 | 0.42 |
| ▸ | PRMT8 | Q9NR22 | 1/20 | 0.42 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Hydrochloric Acid SCHEMBL8742517 | 0.99 | SLC6A2 (0.53) | SLC6A2SLC6A4SLC6A3CYP2D6TACR1 | |
| SCHEMBL8296368 | 0.83 | TACR1 (0.50) | TACR1CCR5 | |
| SCHEMBL8296371 | 0.82 | SLC6A2 (0.43) | SLC6A2SLC6A4SLC6A3TACR1NPFFR1 | |
| SCHEMBL8296155 | 0.81 | SLC6A2 (0.60) | SLC6A2SLC6A4SLC6A3CYP2D6TACR1 | |
| SCHEMBL8296084 | 0.81 | CCR5 (0.64) | CYP2D6TACR1CCR5 | |
| Hydrochloric Acid SCHEMBL8522900 | 0.80 | CCR5 (0.63) | CYP2D6TACR1CCR5 | |
| SCHEMBL8300818 | 0.80 | CCR5 (0.43) | SLC6A2SLC6A4SLC6A3TACR1NPFFR1 | |
| SCHEMBL3466330 | 0.79 | SLC6A2 (0.63) | SLC6A2SLC6A4SLC6A3CYP2D6TACR1 | |
| SCHEMBL3466336 | 0.79 | SLC6A2 (0.63) | SLC6A2SLC6A4SLC6A3CYP2D6TACR1 | |
| Hydrochloric Acid SCHEMBL8521991 | 0.79 | CCR5 (0.42) | SLC6A2SLC6A4SLC6A3TACR1NPFFR1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0512901-B1 | Aminated polycyclic compounds and their enantiomers, process for their preparation and pharmaceutical compositions containing them | SANOFI SA (FR) | 1999-06-23 | — | — | EP | disclosed |
| US-5625060-A | Polycyclic amine compounds and their enantiomers, their method of preparation and pharmaceutical compositions on which they are present | Sanofi, Elf (FR) | 1997-04-29 | — | — | US | disclosed |
| US-5340822-A | Substance P, neurokinin antagonists | ELF SANOFI (FR) | 1994-08-23 | — | — | US | disclosed |
| EP-0512901-A1 | Aminated polycyclic compounds and their enantiomers, process for their preparation and pharmaceutical compositions containing them | SANOFI (FR) | 1992-11-11 | — | — | EP | disclosed |