Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HTR2A | P28223 | 7/20 | 0.36 |
| ▸ | HRH1 | P35367 | 6/20 | 0.36 |
| ▸ | SIGMAR1 | Q99720 | 1/20 | 0.36 |
| ▸ | TP53 | P04637 | 2/20 | 0.35 |
| ▸ | MAPT | P10636 | 2/20 | 0.35 |
| ▸ | TDP1 | Q9NUW8 | 2/20 | 0.33 |
| ▸ | CHRNB2 | P17787 | 1/20 | 0.33 |
| ▸ | CHRNB4 | P30926 | 1/20 | 0.33 |
| ▸ | CHRNA3 | P32297 | 1/20 | 0.33 |
| ▸ | CHRNA4 | P43681 | 1/20 | 0.33 |
| ▸ | TAAR1 | Q96RJ0 | 1/20 | 0.33 |
| ▸ | SLC6A2 | P23975 | 1/20 | 0.33 |
| ▸ | SLC6A4 | P31645 | 1/20 | 0.33 |
| ▸ | MTOR | P42345 | 1/20 | 0.31 |
| ▸ | RAB9A | P51151 | 1/20 | 0.31 |
| ▸ | GRM7 | Q14831 | 1/20 | 0.31 |
| ▸ | CACNA2D1 | P54289 | 1/20 | 0.31 |
| ▸ | CACNA1B | Q00975 | 1/20 | 0.31 |
| ▸ | CACNB1 | Q02641 | 1/20 | 0.31 |
| ▸ | CACNA1C | Q13936 | 1/20 | 0.31 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL11184514 | 0.82 | TP53 (0.49) | HTR2AHRH1SIGMAR1TP53MAPT | |
| Bromide SCHEMBL29026061 | 0.75 | SIGMAR1 (0.44) | HTR2AHRH1SIGMAR1MAPTTDP1 | |
| SCHEMBL28238546 | 0.74 | LMNA (0.46) | HTR2AHRH1SIGMAR1TP53MAPT | |
| SCHEMBL28914293 | 0.74 | NR1H2 (0.43) | HTR2AHRH1TP53MAPTTDP1 | |
| SCHEMBL7093914 | 0.74 | TAAR1 (0.52) | HTR2AHRH1CHRNB2CHRNA4TAAR1 | |
| SCHEMBL2172475 | 0.72 | HRH1 (0.56) | HTR2AHRH1SIGMAR1TDP1TAAR1 | |
| SCHEMBL11354831 | 0.72 | SIGMAR1 (0.38) | HTR2AHRH1SIGMAR1MAPTTDP1 | |
| SCHEMBL3521371 | 0.72 | SIGMAR1 (0.42) | HTR2AHRH1SIGMAR1RAB9A | |
| SCHEMBL30171026 | 0.70 | HRH1 (0.54) | HTR2AHRH1SIGMAR1TDP1TAAR1 | |
| SCHEMBL7986402 | 0.70 | HRH1 (0.42) | HTR2AHRH1SIGMAR1TDP1TAAR1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0625514-B1 | 2-Amino-pyrazin-5-carboxamid derivatives, their preparation and their use in therapy | SYNTHELABO (FR) | 1999-08-25 | — | — | EP | disclosed |
| EP-0625514-A1 | 2-Amino-pyrazin-5-carboxamid derivatives, their preparation and their use in therapy | SYNTHELABO (FR) | 1994-11-23 | — | — | EP | disclosed |