Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HTR1D | P28221 | 2/20 | 0.36 |
| ▸ | HTR1B | P28222 | 2/20 | 0.36 |
| ▸ | THRA | P10827 | 2/20 | 0.36 |
| ▸ | THRB | P10828 | 2/20 | 0.36 |
| ▸ | TAOK3 | Q9H2K8 | 3/20 | 0.35 |
| ▸ | TAOK1 | Q7L7X3 | 2/20 | 0.34 |
| ▸ | HPGD | P15428 | 3/20 | 0.32 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.32 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.32 |
| ▸ | HTT | P42858 | 1/20 | 0.32 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.32 |
| ▸ | NR5A1 | Q13285 | 1/20 | 0.32 |
| ▸ | PDE3B | Q13370 | 1/20 | 0.32 |
| ▸ | PDE3A | Q14432 | 1/20 | 0.32 |
| ▸ | GPR84 | Q9NQS5 | 1/20 | 0.31 |
| ▸ | PTPN1 | P18031 | 1/20 | 0.31 |
| ▸ | NPC1 | O15118 | 1/20 | 0.31 |
| ▸ | TP53 | P04637 | 1/20 | 0.31 |
| ▸ | RAB9A | P51151 | 1/20 | 0.31 |
| ▸ | CNR2 | P34972 | 2/20 | 0.31 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL8303039 | 0.89 | NR5A1 (0.33) | TAOK3NR5A1CNR2CNR1 | |
| SCHEMBL8305524 | 0.87 | HTR1D (0.33) | HTR1DHTR1BTHRATHRBTAOK3 | |
| SCHEMBL8298265 | 0.79 | THRA (0.41) | THRATHRBTAOK3TAOK1PDE3B | |
| SCHEMBL8293940 | 0.79 | THRA (0.35) | HTR1DHTR1BTHRATHRBTAOK3 | |
| SCHEMBL8305593 | 0.71 | XDH (0.40) | HTR1DHTR1BTHRATHRBHPGD | |
| SCHEMBL8294020 | 0.69 | THRA (0.38) | THRATHRBTAOK3TAOK1PDE3B | |
| SCHEMBL8296395 | 0.69 | THRA (0.32) | THRATHRBTAOK3PDE3BPDE3A | |
| SCHEMBL8301428 | 0.69 | THRA (0.34) | THRATHRBTAOK3NR5A1GPR84 | |
| SCHEMBL8299252 | 0.69 | NR5A1 (0.32) | NR5A1GPR84CNR2CNR1 | |
| SCHEMBL10875327 | 0.68 | NR5A1 (0.41) | HTR1BTHRATHRBHPGDKDM4E |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0824520-B1 | 1-FLUOR-5,6,7,8-TETRAHYDROISOQUINOLINE DERIVATIVES AND THEIR USE IN LIQUID CRYSTAL MIXTURES | HOECHST AG (DE) | 1999-10-06 | — | — | EP | disclosed |
| EP-0824520-A1 | 1-FLUOR-5,6,7,8-TETRAHYDROISOQUINOLINE DERIVATIVES AND THEIR USE IN LIQUID CRYSTAL MIXTURES | HOECHST AKTIENGESELLSCHAFT (DE) | 1998-02-25 | — | — | EP | disclosed |
| WO-1996035675-A1 | 1-FLUOR-5,6,7,8-TETRAHYDROISOQUINOLINE DERIVATIVES AND THEIR USE IN LIQUID CRYSTAL MIXTURES | HOECHST AKTIENGESELLSCHAFT (DE) | 1996-11-14 | — | — | WO | disclosed |