Predicted protein targets (top 13)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | THRA | P10827 | 1/20 | 0.34 |
| ▸ | THRB | P10828 | 1/20 | 0.34 |
| ▸ | GPR84 | Q9NQS5 | 3/20 | 0.33 |
| ▸ | NR5A1 | Q13285 | 1/20 | 0.32 |
| ▸ | HTR3E | A5X5Y0 | 2/20 | 0.32 |
| ▸ | HTR3B | O95264 | 2/20 | 0.32 |
| ▸ | HTR3A | P46098 | 2/20 | 0.32 |
| ▸ | HTR3D | Q70Z44 | 2/20 | 0.32 |
| ▸ | HTR3C | Q8WXA8 | 2/20 | 0.32 |
| ▸ | DEGS1 | O15121 | 1/20 | 0.31 |
| ▸ | CNR2 | P34972 | 10/20 | 0.31 |
| ▸ | CNR1 | P21554 | 7/20 | 0.31 |
| ▸ | TAOK3 | Q9H2K8 | 1/20 | 0.30 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL8298273 | 0.88 | GPR84 (0.34) | THRATHRBGPR84HTR3EHTR3B | |
| SCHEMBL8440460 | 0.83 | MAPT (0.30) | — | |
| SCHEMBL8294020 | 0.81 | THRA (0.38) | THRATHRBGPR84HTR3EHTR3B | |
| SCHEMBL8303039 | 0.79 | NR5A1 (0.33) | NR5A1HTR3EHTR3BHTR3AHTR3D | |
| SCHEMBL8299252 | 0.78 | NR5A1 (0.32) | GPR84NR5A1HTR3EHTR3BHTR3A | |
| SCHEMBL8305404 | 0.70 | GPR84 (0.32) | GPR84NR5A1HTR3EHTR3BHTR3A | |
| SCHEMBL8293978 | 0.69 | CNR2 (0.32) | GPR84CNR2CNR1 | |
| SCHEMBL8302527 | 0.68 | NPC1 (0.34) | THRATHRB | |
| SCHEMBL8390797 | 0.67 | FFAR4 (0.35) | THRATHRBGPR84HTR3EHTR3B | |
| SCHEMBL8293940 | 0.67 | THRA (0.35) | THRATHRBGPR84CNR2CNR1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0824521-B1 | 1-FLUOR-6,7-DIHYDRO-5H-ISOQUINOLINE-8-ONE-DERIVATIVES AND THE USE THEREOF IN LIQUID CRYSTALLINE MIXTURES | AVENTIS RES & TECH GMBH & CO (DE) | 1999-12-01 | — | — | EP | disclosed |
| US-5874023-A | ELECTROOPTICS, DISPLAYS | HOECHST AKTIENGESELLSCHAFT (DE) | 1999-02-23 | — | — | US | disclosed |
| EP-0824521-A1 | 1-FLUOR-6,7-DIHYDRO-5H-ISOQUINOLINE-8-ONE-DERIVATIVES AND THE USE THEREOF IN LIQUID CRYSTALLINE MIXTURES | HOECHST AKTIENGESELLSCHAFT (DE) | 1998-02-25 | — | — | EP | disclosed |
| WO-1996035673-A1 | 1-FLUOR-6,7-DIHYDRO-5H-ISOQUINOLINE-8-ONE-DERIVATIVES AND THE USE THEREOF IN LIQUID CRYSTALLINE MIXTURES | HOECHST AKTIENGESELLSCHAFT (DE) | 1996-11-14 | — | — | WO | disclosed |