Predicted protein targets (top 9)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HTR1A | P08908 | 2/20 | 0.51 |
| ▸ | SIGMAR1 | Q99720 | 7/20 | 0.49 |
| ▸ | GBA1 | P04062 | 1/20 | 0.47 |
| ▸ | SLC18A3 | Q16572 | 2/20 | 0.46 |
| ▸ | DPP4 | P27487 | 1/20 | 0.46 |
| ▸ | ACHE | P22303 | 1/20 | 0.44 |
| ▸ | NPY1R | P25929 | 1/20 | 0.44 |
| ▸ | HTT | P42858 | 1/20 | 0.44 |
| ▸ | NPY2R | P49146 | 1/20 | 0.44 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL3176956 | 1.00 | HTR1A (0.51) | HTR1ASIGMAR1GBA1SLC18A3DPP4 | |
| SCHEMBL2885978 | 0.84 | SIGMAR1 (0.54) | HTR1ASIGMAR1GBA1ACHENPY1R | |
| SCHEMBL7069134 | 0.82 | CCR3 (0.50) | HTR1ASIGMAR1HTT | |
| SCHEMBL7068156 | 0.82 | CCR3 (0.50) | HTR1ASIGMAR1HTT | |
| SCHEMBL7071904 | 0.82 | CCR3 (0.50) | HTR1ASIGMAR1HTT | |
| SCHEMBL7068153 | 0.82 | CCR3 (0.50) | HTR1ASIGMAR1HTT | |
| SCHEMBL296401 | 0.82 | SIGMAR1 (0.44) | HTR1ASIGMAR1GBA1ACHENPY1R | |
| SCHEMBL8170360 | 0.81 | HTR1A (0.65) | HTR1ASIGMAR1 | |
| SCHEMBL8170356 | 0.81 | HTR1A (0.65) | HTR1ASIGMAR1 | |
| SCHEMBL22605206 | 0.80 | HTR1A (0.47) | HTR1ASIGMAR1GBA1NPY1RHTT |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1658066-B9 | ADAMANTYLGLYCINE- BASED INHIBITORS OF DIPEPTIDYL PEPTIDASE IV FOR THE TREATMENT OF DIABETES | BRISTOL MYERS SQUIBB CO (US) | 2010-02-24 | — | — | EP | disclosed |
| EP-1658066-B1 | ADAMANTYLGLYCINE- BASED INHIBITORS OF DIPEPTIDYL PEPTIDASE IV FOR THE TREATMENT OF DIABETES | BRISTOL MYERS SQUIBB CO (US) | 2009-09-30 | — | — | EP | disclosed |
| WO-2005012249-A2 | ADAMANTYGLYCINE- BASED INHIBITORS OF DIPEPTIDYL PEPTIDASE IV FOR THE TREATMENT OF DIABETES | BRISTOL-MYERS SQUIBB COMPANY (US) | 2005-02-10 | — | — | WO | disclosed |