Predicted protein targets (top 8)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | SIGMAR1 | Q99720 | 7/20 | 0.54 |
| ▸ | GBA1 | P04062 | 1/20 | 0.53 |
| ▸ | ACHE | P22303 | 1/20 | 0.50 |
| ▸ | HTR1A | P08908 | 2/20 | 0.49 |
| ▸ | NPY1R | P25929 | 1/20 | 0.49 |
| ▸ | HTT | P42858 | 1/20 | 0.49 |
| ▸ | NPY2R | P49146 | 1/20 | 0.49 |
| ▸ | CCR3 | P51677 | 1/20 | 0.48 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL9595473 | 0.89 | SIGMAR1 (0.50) | SIGMAR1GBA1ACHEHTR1A | |
| SCHEMBL3176956 | 0.84 | HTR1A (0.51) | SIGMAR1GBA1ACHEHTR1ANPY1R | |
| SCHEMBL8301747 | 0.84 | HTR1A (0.51) | SIGMAR1GBA1ACHEHTR1ANPY1R | |
| SCHEMBL1286725 | 0.81 | SIGMAR1 (0.50) | SIGMAR1GBA1ACHEHTR1A | |
| SCHEMBL1286746 | 0.81 | SIGMAR1 (0.50) | SIGMAR1GBA1ACHEHTR1A | |
| SCHEMBL10035310 | 0.81 | ALDH1A1 (0.50) | SIGMAR1ACHENPY1RHTTNPY2R | |
| SCHEMBL1318062 | 0.80 | LTA4H (0.52) | SIGMAR1NPY1RHTTNPY2R | |
| SCHEMBL8170360 | 0.80 | HTR1A (0.65) | SIGMAR1HTR1A | |
| SCHEMBL8170356 | 0.80 | HTR1A (0.65) | SIGMAR1HTR1A | |
| SCHEMBL4869898 | 0.79 | GBA1 (0.58) | SIGMAR1GBA1ACHECCR3 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 14 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-8586609-B2 | Aryl-substituted polycyclic amines, method for the production thereof, and use thereof as a medicament | SANOFI-AVENTIS DEUTSCHLAND GMBH (DE) | 2013-11-19 | — | — | US | disclosed |
| US-20100298378-A1 | ARYL-SUBSTITUTED POLYCYCLIC AMINES, METHOD FOR THE PRODUCTION THEREOF, AND USE THEREOF AS A MEDICAMENT | SANOFI-AVENTIS DEUTSCHLAND GMBH (DE) | 2010-11-25 | — | — | US | disclosed |
| US-7838528-B2 | Substituted bicyclic 8-pyrrolidinoxanthines, methods for their production, pharmaceutical formulations and their use | SANOFI-AVENTIS DEUTSCHLAND GMBH (DE) | 2010-11-23 | — | — | US | disclosed |
| US-7838547-B2 | Aryl-substituted polycyclic amines, method for the production thereof, and use thereof as a medicament | SANOFI-AVENTIS DEUTSCHLAND GMBH (DE) | 2010-11-23 | — | — | US | disclosed |
| CN-101006091-B | Aryl-substituted polycyclic amines, method for the production thereof, and use thereof as a medicament | SANOFI AVENTIS DEUTSCHLAND | 2010-09-15 | — | — | CN | disclosed |
| US-20070299077-A1 | ARYL-SUBSTITUTED POLYCYCLIC AMINES, METHOD FOR THE PRODUCTION THEREOF, AND USE THEREOF AS A MEDICAMENT | SANOFI-AVENTIS DEUTSCHLAND GMBH (DE) | 2007-12-27 | — | — | US | disclosed |
| CN-101006091-A | Aryl-substituted polycyclic amines, method for the production thereof, and use thereof as a medicament | SANOFI AVENTIS DEUTSCHLAND (DE) | 2007-07-25 | — | — | CN | disclosed |
| US-20070167468-A1 | SUBSTITUTED BICYCLIC 8-PYRR0LIDINOXANTHINES, METHODS FOR THEIR PRODUCTION, PHARMACEUTICAL FORMULATIONS AND THEIR USE | SANOFI-AVENTIS DEUTSCHLAND GMBH (DE) | 2007-07-19 | — | — | US | disclosed |
| EP-1781663-A2 | ARYL-SUBSTITUTED POLYCYCLIC AMINES, METHOD FOR THE PRODUCTION THEREOF, AND USE THEREOF AS A MEDICAMENT | Sanofi-Aventis Deutschland GmbH (DE) | 2007-05-09 | — | — | EP | disclosed |
| EP-1776372-A1 | SUBSTITUTED, BICYCLIC 8-PYRROLIDINOXANTHINES, METHOD FOR THE PRODUCTION THEREOF AND THEIR USE AS MEDICAMENTS | Sanofi-Aventis Deutschland GmbH (DE) | 2007-04-25 | — | — | EP | disclosed |
| WO-2006018280-A2 | ARYL-SUBSTITUTED POLYCYCLIC AMINES, METHOD FOR THE PRODUCTION THEREOF, AND USE THEREOF AS A MEDICAMENT | SANOFI-AVENTIS DEUTSCHLAND GMBH (DE) | 2006-02-23 | — | — | WO | disclosed |
| WO-2006015701-A1 | SUBSTITUTED, BICYCLIC 8-PYRROLIDINOXANTHINES, METHOD FOR THE PRODUCTION THEREOF AND THEIR USE AS MEDICAMENTS | SANOFI-AVENTIS DEUTSCHLAND GMBH (DE) | 2006-02-16 | — | — | WO | disclosed |
| US-5179090-A | Antiischemic agents; treatment of asthma, bronchitis, heart diseases | DR. KARL THOMAE GMBH (DE) | 1993-01-12 | — | — | US | disclosed |
| EP-0417630-A2 | Condensed diazepinones, process for their preparation, and medicaments containing these compounds | Dr. Karl Thomae GmbH (DE) | 1991-03-20 | — | — | EP | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (3 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20070167468-A1 | SUBSTITUTED BICYCLIC 8-PYRR0LIDINOXANTHINES, METHODS FOR THEIR PRODUCTION, PHARMACEUTICAL FORMULATIONS AND THEIR USE | GPR119, INSR, GCKR | SIGMAR1 4325/4885GBA1 1494/4885ACHE 3555/4885 |
| US-20070299077-A1 | ARYL-SUBSTITUTED POLYCYCLIC AMINES, METHOD FOR THE PRODUCTION THEREOF, AND USE THEREOF AS A MEDICAMENT | PAH, NAT1, AADAT | SIGMAR1 251/4885GBA1 1161/4885ACHE 1269/4885 |
| US-20100298378-A1 | ARYL-SUBSTITUTED POLYCYCLIC AMINES, METHOD FOR THE PRODUCTION THEREOF, AND USE THEREOF AS A MEDICAMENT | PAH, NAT1, AADAT | SIGMAR1 251/4885GBA1 1161/4885ACHE 1269/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.