Predicted protein targets (top 19)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | LMNA | P02545 | 2/20 | 0.53 |
| ▸ | MAPT | P10636 | 6/20 | 0.51 |
| ▸ | GAA | P10253 | 4/20 | 0.51 |
| ▸ | POLB | P06746 | 2/20 | 0.51 |
| ▸ | TP53 | P04637 | 4/20 | 0.50 |
| ▸ | NPC1 | O15118 | 2/20 | 0.50 |
| ▸ | RAB9A | P51151 | 2/20 | 0.50 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.50 |
| ▸ | KDM1A | O60341 | 1/20 | 0.47 |
| ▸ | MEN1 | O00255 | 2/20 | 0.46 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.46 |
| ▸ | ALDH1A1 | P00352 | 5/20 | 0.46 |
| ▸ | NQO1 | P15559 | 1/20 | 0.45 |
| ▸ | HPGD | P15428 | 2/20 | 0.44 |
| ▸ | L3MBTL1 | Q9Y468 | 2/20 | 0.44 |
| ▸ | RECQL | P46063 | 1/20 | 0.44 |
| ▸ | HTT | P42858 | 1/20 | 0.44 |
| ▸ | TSHR | P16473 | 2/20 | 0.44 |
| ▸ | BACE1 | P56817 | 1/20 | 0.44 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL12427204 | 0.81 | NOX4 (0.49) | MAPTPOLBNPC1RAB9AMEN1 | |
| SCHEMBL14600363 | 0.80 | LMNA (0.49) | LMNAMAPTGAAPOLBTP53 | |
| SCHEMBL10841493 | 0.79 | LMNA (0.48) | LMNAMAPTGAAPOLBTP53 | |
| SCHEMBL24478670 | 0.78 | MGLL (0.46) | POLBTP53NPC1RAB9ASMN1; SMN2 | |
| SCHEMBL8299963 | 0.77 | MEN1 (0.52) | MAPTNPC1RAB9AKDM1AMEN1 | |
| SCHEMBL20134663 | 0.77 | KDM1A (0.62) | KDM1A | |
| SCHEMBL10556235 | 0.76 | KMT2A (0.53) | LMNAMAPTGAAPOLBNPC1 | |
| SCHEMBL25278937 | 0.76 | HTT (0.55) | LMNAMAPTGAASMN1; SMN2MEN1 | |
| SCHEMBL3577171 | 0.75 | MAPT (0.47) | LMNAMAPTGAAPOLBTP53 | |
| SCHEMBL15448368 | 0.75 | DRD2 (0.55) | LMNAGAANPC1RAB9ASMN1; SMN2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-7166603-B2 | Dihydropyrimidone inhibitors of calcium channel function | BRISTOL-MYERS SQUIBB CO. (US) | 2007-01-23 | — | — | US | disclosed |
| WO-2005009392-A2 | DIHYDROPYRIMIDONE INHIBITORS OF CALCIUM CHANNEL FUNCTION | BRISTOL-MYERS SQUIBB COMPANY (US) | 2005-02-03 | — | — | WO | disclosed |