Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MEN1 | O00255 | 1/20 | 0.52 |
| ▸ | NPC1 | O15118 | 1/20 | 0.52 |
| ▸ | RAB9A | P51151 | 1/20 | 0.52 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.52 |
| ▸ | PLCG1 | P19174 | 1/20 | 0.50 |
| ▸ | MGLL | Q99685 | 3/20 | 0.47 |
| ▸ | MCHR2 | Q969V1 | 1/20 | 0.47 |
| ▸ | MCHR1 | Q99705 | 1/20 | 0.47 |
| ▸ | KDM1A | O60341 | 1/20 | 0.47 |
| ▸ | CTSG | P08311 | 2/20 | 0.46 |
| ▸ | CMA1 | P23946 | 2/20 | 0.46 |
| ▸ | HRH3 | Q9Y5N1 | 1/20 | 0.46 |
| ▸ | LTA4H | P09960 | 1/20 | 0.45 |
| ▸ | NR1H4 | Q96RI1 | 1/20 | 0.44 |
| ▸ | NTRK1 | P04629 | 1/20 | 0.43 |
| ▸ | IGF1R | P08069 | 1/20 | 0.43 |
| ▸ | FGFR1 | P11362 | 1/20 | 0.43 |
| ▸ | NTRK3 | Q16288 | 1/20 | 0.43 |
| ▸ | NTRK2 | Q16620 | 1/20 | 0.43 |
| ▸ | USP2 | O75604 | 1/20 | 0.42 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL2234870 | 0.84 | MEN1 (0.72) | MEN1NPC1RAB9AKMT2AKDM1A | |
| SCHEMBL12427204 | 0.81 | NOX4 (0.49) | MEN1NPC1RAB9AKMT2AMGLL | |
| SCHEMBL14600367 | 0.80 | NR1H4 (0.48) | MEN1NPC1RAB9AKMT2APLCG1 | |
| SCHEMBL11397473 | 0.78 | MAPT (0.45) | MEN1KMT2ALTA4HALDH1A1MAPT | |
| SCHEMBL8301822 | 0.77 | LMNA (0.53) | MEN1NPC1RAB9AKMT2AKDM1A | |
| SCHEMBL10556235 | 0.76 | KMT2A (0.53) | MEN1NPC1RAB9AKMT2AALDH1A1 | |
| SCHEMBL15448368 | 0.75 | DRD2 (0.55) | MEN1NPC1RAB9AKMT2AMGLL | |
| SCHEMBL3577171 | 0.75 | MAPT (0.47) | MEN1NPC1RAB9AKMT2AKDM1A | |
| SCHEMBL6081782 | 0.75 | LTA4H (0.55) | MEN1NPC1RAB9AKMT2APLCG1 | |
| SCHEMBL6081644 | 0.75 | LTA4H (0.67) | MEN1NPC1RAB9AKMT2AMCHR1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-7166603-B2 | Dihydropyrimidone inhibitors of calcium channel function | BRISTOL-MYERS SQUIBB CO. (US) | 2007-01-23 | — | — | US | disclosed |
| WO-2005009392-A2 | DIHYDROPYRIMIDONE INHIBITORS OF CALCIUM CHANNEL FUNCTION | BRISTOL-MYERS SQUIBB COMPANY (US) | 2005-02-03 | — | — | WO | disclosed |