Predicted protein targets (top 5)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MCL1 | Q07820 | 15/20 | 0.57 |
| ▸ | ADA | P00813 | 2/20 | 0.52 |
| ▸ | MTNR1A | P48039 | 3/20 | 0.50 |
| ▸ | MTNR1B | P49286 | 3/20 | 0.50 |
| ▸ | BCL2 | P10415 | 1/20 | 0.48 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL6919592 | 0.83 | HTR7 (0.57) | MCL1BCL2 | |
| SCHEMBL19172460 | 0.81 | MCL1 (0.58) | MCL1ADAMTNR1AMTNR1BBCL2 | |
| SCHEMBL28758520 | 0.81 | MTNR1A (0.53) | MCL1ADAMTNR1AMTNR1B | |
| SCHEMBL6724557 | 0.80 | MTNR1A (0.46) | MCL1MTNR1AMTNR1BBCL2 | |
| SCHEMBL27593266 | 0.79 | MTNR1A (0.45) | MCL1MTNR1AMTNR1B | |
| SCHEMBL14930466 | 0.78 | ALDH1A1 (0.60) | — | |
| SCHEMBL14926509 | 0.77 | ALDH1A1 (0.58) | MTNR1A | |
| SCHEMBL14930467 | 0.76 | THRA (0.56) | MTNR1A | |
| SCHEMBL8163392 | 0.76 | MAPK1 (0.60) | MTNR1AMTNR1B | |
| SCHEMBL14926510 | 0.76 | THRA (0.56) | MTNR1A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2004089915-A1 | PIPERAZINE DERIVATIVE RENIN INHIBITORS | WARNER-LAMBERT COMPANY LLC (US) | 2004-10-21 | — | — | WO | disclosed |