Predicted protein targets (top 13)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | DRD2 | P14416 | 11/20 | 0.34 |
| ▸ | HTR1A | P08908 | 3/20 | 0.34 |
| ▸ | NR3C2 | P08235 | 1/20 | 0.33 |
| ▸ | DRD3 | P35462 | 8/20 | 0.33 |
| ▸ | DRD4 | P21917 | 7/20 | 0.33 |
| ▸ | HTR2A | P28223 | 4/20 | 0.33 |
| ▸ | DRD1 | P21728 | 3/20 | 0.33 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.31 |
| ▸ | HTR1D | P28221 | 2/20 | 0.31 |
| ▸ | HTR1B | P28222 | 2/20 | 0.31 |
| ▸ | SLC6A4 | P31645 | 2/20 | 0.31 |
| ▸ | KCNH2 | Q12809 | 2/20 | 0.31 |
| ▸ | DRD5 | P21918 | 2/20 | 0.31 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL427031 | 0.76 | MMP12 (0.39) | DRD2HTR1ANR3C2DRD3DRD4 | |
| SCHEMBL8307023 | 0.69 | DRD2 (0.38) | DRD2HTR1ANR3C2DRD3DRD4 | |
| SCHEMBL8302748 | 0.67 | DRD2 (0.39) | DRD2HTR1ADRD3DRD4HTR2A | |
| SCHEMBL426861 | 0.66 | SMYD3 (0.43) | DRD2HTR1AHTR1DHTR1BSLC6A4 | |
| SCHEMBL8304724 | 0.65 | DRD2 (0.34) | DRD2NR3C2DRD3DRD4HTR2A | |
| SCHEMBL428017 | 0.65 | MMP12 (0.40) | DRD2HTR1ANR3C2DRD3DRD4 | |
| SCHEMBL7854062 | 0.65 | KDM4E (0.36) | NR3C2KDM4E | |
| SCHEMBL8303552 | 0.64 | DRD2 (0.33) | DRD2HTR1A | |
| SCHEMBL8301874 | 0.62 | DRD2 (0.37) | DRD2HTR1ANR3C2DRD3DRD4 | |
| SCHEMBL8303055 | 0.62 | DRD2 (0.37) | DRD2HTR1ANR3C2DRD3DRD4 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0548254-B1 | 6- OR 7-(IMIDAZOLIDIN-2-YLIDENEAMINO)-1,4-BENZOXAZINES AS ALPHA ADRENERGIC AGENTS | ALLERGAN INC (US) | 1999-06-02 | — | — | EP | disclosed |
| US-5091528-A | Antiglaucoma, antidiarrhea agents, diuretics, vasoconstrictors | ALLERGAN, INC. (US) | 1992-02-25 | — | — | US | disclosed |