Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CYP2D6 | P10635 | 3/20 | 0.43 |
| ▸ | CYP3A4 | P08684 | 3/20 | 0.43 |
| ▸ | CYP19A1 | P11511 | 2/20 | 0.43 |
| ▸ | CYP1A2 | P05177 | 2/20 | 0.43 |
| ▸ | CYP2C9 | P11712 | 2/20 | 0.43 |
| ▸ | CYP2C19 | P33261 | 2/20 | 0.43 |
| ▸ | CHRNA7 | P36544 | 1/20 | 0.41 |
| ▸ | LMNA | P02545 | 2/20 | 0.38 |
| ▸ | HTT | P42858 | 2/20 | 0.38 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.38 |
| ▸ | ATM | Q13315 | 1/20 | 0.38 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.38 |
| ▸ | MCHR1 | Q99705 | 1/20 | 0.37 |
| ▸ | PDE3B | Q13370 | 2/20 | 0.36 |
| ▸ | PDE3A | Q14432 | 2/20 | 0.36 |
| ▸ | TP53 | P04637 | 1/20 | 0.36 |
| ▸ | PDE2A | O00408 | 1/20 | 0.35 |
| ▸ | BAZ2B | Q9UIF8 | 1/20 | 0.35 |
| ▸ | HTR2A | P28223 | 1/20 | 0.35 |
| ▸ | HTR2C | P28335 | 1/20 | 0.35 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL8303218 | 0.79 | MEN1 (0.39) | CYP19A1LMNAHTTALDH1A1POLB | |
| SCHEMBL8873628 | 0.79 | L3MBTL1 (0.47) | CYP3A4CYP2C19ALDH1A1HTR2AHTR2C | |
| SCHEMBL8304050 | 0.76 | HRH2 (0.47) | CYP3A4CYP19A1SMN1; SMN2ALDH1A1USP2 | |
| SCHEMBL8303793 | 0.76 | GAA (0.49) | CYP2D6CYP2C19LMNAHTTSMN1; SMN2 | |
| Hydrochloric Acid SCHEMBL8306472 | 0.75 | HRH2 (0.46) | CYP3A4CYP19A1SMN1; SMN2ALDH1A1USP2 | |
| SCHEMBL9520302 | 0.74 | RAB9A (0.45) | SMN1; SMN2TSHR | |
| Hydrochloric Acid SCHEMBL9522648 | 0.73 | RAB9A (0.47) | SMN1; SMN2TSHR | |
| SCHEMBL6324442 | 0.69 | CHRNA7 (0.47) | CYP2D6CYP3A4CYP19A1CHRNA7LMNA | |
| SCHEMBL10673408 | 0.67 | GLB1 (0.52) | — | |
| SCHEMBL27774380 | 0.67 | POLB (0.56) | CYP2D6CYP3A4CYP1A2CYP2C9CYP2C19 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0665228-B1 | Pharmaceutical compositions containing 3-phenylsulfonyl-3,7-diazabicyclo 3,3,1 nonanes | SOLVAY PHARM GMBH (DE) | 1999-07-14 | — | — | EP | disclosed |
| US-5635511-A | ACID ADDITION SALT DERIVATIVES; ANTIARRHYTHMIA AGENTS; ACTIVE SUPPRESSION OF EXTRASYSTOLES, VENTRICULAR FLUTTERS AND FIBRILLATIONS | KALI-CHEMIE PHARMA GMBH (DE) | 1997-06-03 | — | — | US | disclosed |
| US-5576327-A | Treatment of heart rhythym disorders by administration of 3-phenylsulfonyl-3, 7-diazabicyclo[3.3.1]nonane compounds | KALI-CHEMIE PHARMA GMBH (DE) | 1996-11-19 | — | — | US | disclosed |
| EP-0665228-A1 | Pharmaceutical compositions containing 3-phenylsulfonyl-3,7-diazabicyclo 3,3,1 nonanes | Kali-Chemie Pharma GmbH (DE) | 1995-08-02 | — | — | EP | disclosed |