Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CHRNA7 | P36544 | 1/20 | 0.47 |
| ▸ | LMNA | P02545 | 3/20 | 0.39 |
| ▸ | HTT | P42858 | 1/20 | 0.39 |
| ▸ | ATM | Q13315 | 1/20 | 0.39 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.39 |
| ▸ | CYP3A4 | P08684 | 2/20 | 0.39 |
| ▸ | BAZ2B | Q9UIF8 | 1/20 | 0.39 |
| ▸ | HTR2A | P28223 | 1/20 | 0.38 |
| ▸ | HTR2C | P28335 | 1/20 | 0.38 |
| ▸ | HTR2B | P41595 | 1/20 | 0.38 |
| ▸ | MAOA | P21397 | 1/20 | 0.38 |
| ▸ | MAOB | P27338 | 1/20 | 0.38 |
| ▸ | MEN1 | O00255 | 1/20 | 0.38 |
| ▸ | POLB | P06746 | 1/20 | 0.38 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.38 |
| ▸ | GAA | P10253 | 1/20 | 0.38 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.37 |
| ▸ | PSEN1 | P49768 | 1/20 | 0.37 |
| ▸ | PSEN2 | P49810 | 1/20 | 0.37 |
| ▸ | APH1B | Q8WW43 | 1/20 | 0.37 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL6317043 | 0.77 | CYP3A4 (0.50) | CHRNA7HTTCYP3A4BAZ2BHTR2A | |
| SCHEMBL9635205 | 0.76 | TSHR (0.45) | LMNAMEN1POLBKMT2AGAA | |
| Perchlorate SCHEMBL6368227 | 0.75 | CYP3A4 (0.45) | CHRNA7HTTCYP3A4BAZ2BHTR2A | |
| SCHEMBL27774380 | 0.70 | POLB (0.56) | CHRNA7LMNASMN1; SMN2CYP3A4MEN1 | |
| SCHEMBL8303345 | 0.69 | CYP2D6 (0.43) | CHRNA7LMNAHTTATMSMN1; SMN2 | |
| SCHEMBL8797691 | 0.68 | MAOA (0.61) | CHRNA7LMNAHTTCYP3A4BAZ2B | |
| SCHEMBL9594739 | 0.67 | NOTUM (0.61) | CHRNA7LMNAHTTCYP3A4BAZ2B | |
| SCHEMBL4408673 | 0.66 | CHRNA7 (0.76) | CHRNA7LMNACYP3A4BAZ2BMEN1 | |
| SCHEMBL10423949 | 0.66 | ENPP2 (0.59) | CHRNA7LMNAHTTCYP3A4BAZ2B | |
| SCHEMBL23088859 | 0.64 | CHRNA7 (1.00) | CHRNA7LMNAMAPTCA12CA1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-6887881-B1 | Bispidine compounds useful in the treatment of cardiac arrythmias | ASTRAZENECA AB (SE) | 2005-05-03 | — | — | US | disclosed |